International Journal of Medical Sciences

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19 November 2018

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Int J Med Sci 2018; 15(9):915-920. doi:10.7150/ijms.26523

Research Paper

Co-infection Of Ureaplasma urealyticum And Human Papilloma Virus In Asymptomatic Sexually Active Individuals

Sang Il Kim1, Joo Hee Yoon1, Dong Choon Park1, Dong Sup Lee2, Seung Ju Lee2, Hyun Sop Choe2, Jin Hwi Kim3, Tae Chul Park3, Sung Jong Lee1✉

1. Department of Obstetrics and Gynecology, College of Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Republic of Korea
2. Department of Urology, College of Medicine, St. Vincent's Hospital, The Catholic University of Korea, Suwon, Republic of Korea
3. Department of Obstetrics and Gynecology, College of Medicine, Uijeongbu St. Mary Hospital, The Catholic University of Korea, Uijeongbu, Republic of Korea

Abstract

This study aimed to determine the role of asymptomatic bacterial sexually transmitted infections (STIs), such as Chlamydia trachomatis (Ct), Mycoplasma genitalium (Mg), Mycoplasma hominis (Mh), and Ureaplasma urealyticum (Uu) in human papillomavirus (HPV) infection.

In total, 264 asymptomatic outpatients aged between 21 and 80 years were prospectively enrolled in this study during routine gynecological screening tests. Specimens collected with a Cervex Brush were routinely analyzed with the Hybrid Capture 2 assay for HPV. Simultaneously, a specimen obtained with an endocervical swab was used to detect Ct and Mg with a monoplex real-time polymerase chain reaction (PCR) and to confirm Mh and Uu with a Mycoplasma IST 2 kit.

The detection rates (%) of HPV, Ct, Mg, Mh, and Uu were 82/264 (31.1), 6/264 (2.3), 5/264 (1.9), 16/264 (6.1), and 95/264 (36.0), respectively. Of 95 Uu, 32 (33.7%) showed high density colonization (HDC, ≥104 color-changing units/mL). HDC-Uu was significantly associated with HPV infection (p=0.014, chi-square test). Mg infection and Mh infection were not associated with HPV infection (p=0.981 and p=0.931, chi-square test). Age was not associated with HPV infection or bacterial infection.

Our data suggested that asymptomatic HDC-Uu was closely associated with HPV infection. Therefore, simultaneous evaluation for Uu and HPV should be performed during gynecological screening, even in asymptomatic individuals.

Keywords: Mycoplasma, Ureaplasma urealyticum, human papillomavirus

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How to cite this article:
Kim SI, Yoon JH, Park DC, Lee DS, Lee SJ, Choe HS, Kim JH, Park TC, Lee SJ. Co-infection Of Ureaplasma urealyticum And Human Papilloma Virus In Asymptomatic Sexually Active Individuals. Int J Med Sci 2018; 15(9):915-920. doi:10.7150/ijms.26523. Available from http://www.medsci.org/v15p0915.htm