International Journal of Medical Sciences

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21 July 2018

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Int J Med Sci 2018; 15(6):653-658. doi:10.7150/ijms.23733

Research Paper

Impact of matrix metalloproteinase-11 gene polymorphisms upon the development and progression of hepatocellular carcinoma

Bin Wang1#, Chin-Jung Hsu2,3#, Hsiang-Lin Lee4,5,6, Chia-Hsuan Chou4, Chen-Ming Su7, Shun-Fa Yang4,8✉, Chih-Hsin Tang9,10,11✉

1. Department of Hepatobiliary Surgery, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China
2. School of Chinese Medicine, China Medical University, Taichung, Taiwan
3. Department of Orthopedic Surgery, China Medical University Hospital, Taichung, Taiwan
4. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
5. School of Medicine, Chung Shan Medical University, Taichung, Taiwan
6. Department of Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan
7. Department of Biomedical Sciences Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China
8. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan
9. Department of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan
10. Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan
11. Department of Biotechnology, College of Health Science, Asia University, Taichung, Taiwan
# These authors have contributed equally to this work

Abstract

Hepatocellular carcinoma (HCC) is a liver malignancy and a major cause of cancer mortality worldwide. Matrix metalloproteinase-11 (MMP-11), also known as stromelysin-3, plays a critical role during tumor migration, invasion and metastasis. Here, we report on the association between five single nucleotide polymorphisms (SNPs) - rs738791, rs2267029, rs738792, rs28382575, and rs131451 - of the MMP-11 gene and HCC susceptibility, as well as clinical outcomes, in 293 patients with HCC and in 586 cancer-free controls. We found that carriers of the CT+TT allele of the rs738791 variant were at greater risk of HCC compared with wild-type (CC) carriers. Moreover, carriers of at least one C allele (C/T+C/C genotype) at the MMP-11 SNP rs738792 were likely to progress to Child-Pugh B or C grade, while individuals with at least one C allele (C/T+C/C genotype) at the MMP-11 SNP rs28382575 were at higher risk of developing stage III/IV disease, large tumors or lymph node metastasis. We believe that genetic variations in the MMP-11 gene may help to predict early-stage HCC and act as reliable biomarkers for HCC progression.

Keywords: MMP-11 polymorphisms, Hepatocellular carcinoma, Single nucleotide polymorphism, Susceptibility

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How to cite this article:
Wang B, Hsu CJ, Lee HL, Chou CH, Su CM, Yang SF, Tang CH. Impact of matrix metalloproteinase-11 gene polymorphisms upon the development and progression of hepatocellular carcinoma. Int J Med Sci 2018; 15(6):653-658. doi:10.7150/ijms.23733. Available from http://www.medsci.org/v15p0653.htm