Int J Med Sci 2018; 15(5):430-435. doi:10.7150/ijms.23428 This issue Cite

Review

DJ-1 in Ocular Diseases: A Review

Cong Liu*, Xiufen Liu*, Jing Qi, Om Prakash Pant, Cheng-wei Lu, Jilong Hao

Department of Ophthalmology, The First Hospital of Jilin University, Jilin, China.
*Cong Liu and Xiufen Liu contribute equally to this manuscript.

Citation:
Liu C, Liu X, Qi J, Pant OP, Lu Cw, Hao J. DJ-1 in Ocular Diseases: A Review. Int J Med Sci 2018; 15(5):430-435. doi:10.7150/ijms.23428. https://www.medsci.org/v15p0430.htm
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Abstract

Protein deglycase DJ-1 (Parkinson disease protein 7) is a 20 kDa protein encoded by PARK7 gene. It is also known as a redox-sensitive chaperone and sensor that protect cells against oxidative stress-induced cell death in many human diseases. Though increasing evidence implicates that DJ-1 may also participate in ocular diseases, the overview of DJ-1 in ocular diseases remains elusive. In this review, we discuss the role as well as the underlying molecular mechanisms of DJ-1 in ocular diseases, including Fuchs endothelial corneal dystrophy (FECD), age-related macular degeneration (AMD), cataracts, and ocular neurodegenerative diseases, highlighting that DJ-1 may serve as a very striking therapeutic target for ocular diseases.

Keywords: DJ-1, ocular disease, oxidative stress


Citation styles

APA
Liu, C., Liu, X., Qi, J., Pant, O.P., Lu, C.w., Hao, J. (2018). DJ-1 in Ocular Diseases: A Review. International Journal of Medical Sciences, 15(5), 430-435. https://doi.org/10.7150/ijms.23428.

ACS
Liu, C.; Liu, X.; Qi, J.; Pant, O.P.; Lu, C.w.; Hao, J. DJ-1 in Ocular Diseases: A Review. Int. J. Med. Sci. 2018, 15 (5), 430-435. DOI: 10.7150/ijms.23428.

NLM
Liu C, Liu X, Qi J, Pant OP, Lu Cw, Hao J. DJ-1 in Ocular Diseases: A Review. Int J Med Sci 2018; 15(5):430-435. doi:10.7150/ijms.23428. https://www.medsci.org/v15p0430.htm

CSE
Liu C, Liu X, Qi J, Pant OP, Lu Cw, Hao J. 2018. DJ-1 in Ocular Diseases: A Review. Int J Med Sci. 15(5):430-435.

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