Int J Med Sci
2018; 15(5):417-424.
doi:10.7150/ijms.22854 This issueCite
Research Paper
Nutrients restriction upregulates adiponectin in epicardial or subcutaneous adipose tissue: impact in de novo heart failure patients
Rosa M Agra1,2,3, Ángel Fernández-Trasancos2, Esther Díaz-Rodríguez2, Alberto Cordero4, Alfonso Varela-Román1,2,3, Inés Gómez-Otero1,2,3, J Nicolás López- Canoa1, Ángel Luis Fernández3,5, José Manuel Martínez-Cereijo5, José Ramón González-Juanatey1,2,3, Sonia Eiras2,3✉
1. Cardiovascular Area and Coronary Unit, University Clinical Hospital of Santiago de Compostela, Spain 2. Cardiology Group, Health Research Institute of Santiago de Compostela, Spain 3. CIBERCV: Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares 4. Cardiology Department, University Hospital of San Juan, Alicante, Spain 5. Heart Surgery, University Clinical Hospital of Santiago de Compostela, Spain
✉ Corresponding author: Sonia Eiras Penas, Laboratorio 6. IDIS. Planta -2. C/Choupana s/n. Complejo Hospitalario Universitario de Santiago de Compostela. 15706 Santiago de Compostela (Spain) e-mail: sonia.eiras.penases; Tel:0034981955074
Citation:
Agra RM, Fernández-Trasancos Á, Díaz-Rodríguez E, Cordero A, Varela-Román A, Gómez-Otero I, Canoa JNL, Fernández ÁL, Martínez-Cereijo JM, González-Juanatey JR, Eiras S. Nutrients restriction upregulates adiponectin in epicardial or subcutaneous adipose tissue: impact in de novo heart failure patients. Int J Med Sci 2018; 15(5):417-424. doi:10.7150/ijms.22854. https://www.medsci.org/v15p0417.htm
Background: Hyperadiponectinemia is an indicator of worse outcomes in advanced heart failure (HF), its role in de novo HF is less clear.
Objective: Because this protein is a hormone with starvation properties, we wanted to know its association with nutritional state and its regulator factors in de novo HF.
Methods: Adiponectin circulating levels were determined by ELISA at discharge in patients admitted for de novo HF (n=74). Nutritional status was determined by CONUT score. Univariate and multivariate Cox regression analyses were employed to calculate the estimated hazard ratio (HR) with 95% confidence interval (CI) for death or all-cause readmission. Stromal vascular cells (SVC) of EAT and subcutaneous adipose tissue (SAT) from patients (n=5) underwent heart surgery were induced to adipogenesis for 18 days. Then, cells were cultured with complete or starved medium for 8 hours. At the end, adiponectin expression levels were analysed by real time polymerase chain reaction.
Results: Patients were grouped regarding nutritional status. There was a strong association between high adiponectin levels and failing nutritional status. Those patients with worse nutritional state had the highest adiponectin and proBNP levels at discharge (p<0.01). Both proteins were slightly correlated (p<0.05). However, only high adiponectin levels were independently associated with death or all-cause readmission. Nutrients starvation upregulated adiponectin expression levels in adipogenesis-induced SVC from EAT or SAT.
Conclusions: Worse nutritional state in de novo HF patients is associated with higher adiponectin plasma levels. Their levels were upregulated in adipose cells after being nutrients-starved. These results may help us to understand the adiponectin paradox in HF.
Citation styles
APA
Agra, R.M., Fernández-Trasancos, Á., Díaz-Rodríguez, E., Cordero, A., Varela-Román, A., Gómez-Otero, I., Canoa, J.N.L., Fernández, Á.L., Martínez-Cereijo, J.M., González-Juanatey, J.R., Eiras, S. (2018). Nutrients restriction upregulates adiponectin in epicardial or subcutaneous adipose tissue: impact in de novo heart failure patients. International Journal of Medical Sciences, 15(5), 417-424. https://doi.org/10.7150/ijms.22854.
ACS
Agra, R.M.; Fernández-Trasancos, Á.; Díaz-Rodríguez, E.; Cordero, A.; Varela-Román, A.; Gómez-Otero, I.; Canoa, J.N.L.; Fernández, Á.L.; Martínez-Cereijo, J.M.; González-Juanatey, J.R.; Eiras, S. Nutrients restriction upregulates adiponectin in epicardial or subcutaneous adipose tissue: impact in de novo heart failure patients. Int. J. Med. Sci. 2018, 15 (5), 417-424. DOI: 10.7150/ijms.22854.
NLM
Agra RM, Fernández-Trasancos Á, Díaz-Rodríguez E, Cordero A, Varela-Román A, Gómez-Otero I, Canoa JNL, Fernández ÁL, Martínez-Cereijo JM, González-Juanatey JR, Eiras S. Nutrients restriction upregulates adiponectin in epicardial or subcutaneous adipose tissue: impact in de novo heart failure patients. Int J Med Sci 2018; 15(5):417-424. doi:10.7150/ijms.22854. https://www.medsci.org/v15p0417.htm
CSE
Agra RM, Fernández-Trasancos Á, Díaz-Rodríguez E, Cordero A, Varela-Román A, Gómez-Otero I, Canoa JNL, Fernández ÁL, Martínez-Cereijo JM, González-Juanatey JR, Eiras S. 2018. Nutrients restriction upregulates adiponectin in epicardial or subcutaneous adipose tissue: impact in de novo heart failure patients. Int J Med Sci. 15(5):417-424.
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