International Journal of Medical Sciences

Impact factor
2.284

13 November 2018

ISSN 1449-1907 News feeds of published articles

Manuscript login | Account

open access Global reach, higher impact

Journal of Genomics in PubMed Central. Submit manuscript now...

Theranostics

Journal of Cancer

International Journal of Biological Sciences

Journal of Genomics

Journal of Bone and Joint Infection (JBJI)

Oncomedicine

Journal of Biomedicine

Nanotheranostics

PubMed Central Indexed in Journal Impact Factor

Int J Med Sci 2018; 15(3):217-222. doi:10.7150/ijms.22402

Research Paper

Association of Genetic Variants of Small Non-Coding RNAs with Survival in Colorectal Cancer

Jiunn-Bey Pao1*, Te-Ling Lu2*, Wen-Chien Ting3,4,5, Lu-Min Chen6, Bo-Ying Bao2,7,8✉

1. Department of Pharmacy, Zhongxing Branch, Taipei City Hospital, Taipei, Taiwan
2. Department of Pharmacy, China Medical University, Taichung, Taiwan
3. Department of Colorectal Surgery, China Medical University Hospital, Taichung, Taiwan
4. Division of Colorectal Surgery, Department of Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan
5. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan
6. Department of Obstetrics and Gynecology, China Medical University Hospital, Taichung, Taiwan
7. Sex Hormone Research Center, China Medical University Hospital, Taichung, Taiwan
8. Department of Nursing, Asia University, Taichung, Taiwan
* Jiunn-Bey Pao and Te-Ling Lu contributed equally to this work.

Abstract

Background: Single nucleotide polymorphisms (SNPs) of small non-coding RNAs (sncRNAs) can influence sncRNA function and target gene expression to mediate the risk of certain diseases. The aim of the present study was to evaluate the prognostic relevance of sncRNA SNPs for colorectal cancer, which has not been well characterized to date.

Methods: We comprehensively examined 31 common SNPs of sncRNAs, and assessed the impact of these variants on survival in a cohort of 188 patients with colorectal cancer.

Results: Three SNPs were significantly associated with survival of patients with colorectal cancer after correction for multiple testing, and two of the SNPs (hsa-mir-196a-2 rs11614913 and U85 rs714775) remained significant in multivariate analyses. Additional in silico analysis provided further evidence of this association, since the expression levels of the target genes of the hsa-miR-196a (HOXA7, HOXB8, and AKT1) were significantly correlated with colorectal cancer progression. Furthermore, Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses indicated that hsa-miR-196a is associated with well-known oncogenic pathways, including cellular protein modification process, mitotic cell cycle, adherens junction, and extracellular matrix receptor interaction pathways.

Conclusion: Our results suggest that SNPs of sncRNAs could play a critical role in cancer progression, and that hsa-miR-196a might be a valuable biomarker or therapeutic target for colorectal cancer patients.

Keywords: colorectal cancer, survival, small non-coding RNA, single nucleotide polymorphism, biomarker

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Pao JB, Lu TL, Ting WC, Chen LM, Bao BY. Association of Genetic Variants of Small Non-Coding RNAs with Survival in Colorectal Cancer. Int J Med Sci 2018; 15(3):217-222. doi:10.7150/ijms.22402. Available from http://www.medsci.org/v15p0217.htm