Int J Med Sci 2018; 15(2):170-175. doi:10.7150/ijms.22513 This issue Cite

Research Paper

Variations in the AURKA Gene: Biomarkers for the Development and Progression of Hepatocellular Carcinoma

Bin Wang1, Chin-Jung Hsu2,3, Chia-Hsuan Chou4, Hsiang-Lin Lee4,5, Whei-Ling Chiang6, Chen-Ming Su7, Hsiao-Chi Tsai8, Shun-Fa Yang4,9✉, Chih-Hsin Tang10,11,12✉

1. Department of Hepatobiliary Surgery, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China;
2. School of Chinese Medicine, China Medical University, Taichung, Taiwan;
3. Department of Orthopedic Surgery, China Medical University Hospital, Taichung, Taiwan;
4. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan;
5. Department of Surgery, Chung Shan Medical University Hospital, Taichung, Taiwan;
6. School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan;
7. Department of Biomedical Sciences Laboratory, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, China;
8. Department of Scientific Education, Qinghai Red Cross Hospital, Xining City, Qinghai, China;
9. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan;
10. Department of Pharmacology, School of Medicine, China Medical University, Taichung, Taiwan;
11. Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan;
12. Department of Biotechnology, College of Health Science, Asia University, Taichung, Taiwan.

Citation:
Wang B, Hsu CJ, Chou CH, Lee HL, Chiang WL, Su CM, Tsai HC, Yang SF, Tang CH. Variations in the AURKA Gene: Biomarkers for the Development and Progression of Hepatocellular Carcinoma. Int J Med Sci 2018; 15(2):170-175. doi:10.7150/ijms.22513. https://www.medsci.org/v15p0170.htm
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Abstract

Hepatocellular carcinoma (HCC) is a liver malignancy and a major cause of cancer mortality worldwide. AURKA (aurora kinase A) is a mitotic serine/threonine kinase that functions as an oncogene and plays a critical role in hepatocarcinogenesis. We report on the association between 4 single nucleotide polymorphisms (SNPs) of the AURKA gene (rs1047972, rs2273535, rs2064836, and rs6024836) and HCC susceptibility as well as clinical outcomes in 312 patients with HCC and in 624 cancer-free controls. We found that carriers of the TT allele of the variant rs1047972 were at greater risk of HCC compared with wild-type (CC) carriers. Moreover, carriers of at least one A allele in rs2273535 were less likely to progress to stage III/IV disease, develop large tumors or be classified into Child-Pugh class B or C. Individuals with at least one G allele at AURKA SNP rs2064863 were at lower risk of developing large tumors or progressing to Child-Pugh grade B or C. Our results indicate that genetic variations in the AURKA gene may serve as an important predictor of early-stage HCC and be a reliable biomarker for the development of HCC.

Keywords: AURKA polymorphisms, Hepatocellular carcinoma, Single nucleotide polymorphism, Susceptibility.


Citation styles

APA
Wang, B., Hsu, C.J., Chou, C.H., Lee, H.L., Chiang, W.L., Su, C.M., Tsai, H.C., Yang, S.F., Tang, C.H. (2018). Variations in the AURKA Gene: Biomarkers for the Development and Progression of Hepatocellular Carcinoma. International Journal of Medical Sciences, 15(2), 170-175. https://doi.org/10.7150/ijms.22513.

ACS
Wang, B.; Hsu, C.J.; Chou, C.H.; Lee, H.L.; Chiang, W.L.; Su, C.M.; Tsai, H.C.; Yang, S.F.; Tang, C.H. Variations in the AURKA Gene: Biomarkers for the Development and Progression of Hepatocellular Carcinoma. Int. J. Med. Sci. 2018, 15 (2), 170-175. DOI: 10.7150/ijms.22513.

NLM
Wang B, Hsu CJ, Chou CH, Lee HL, Chiang WL, Su CM, Tsai HC, Yang SF, Tang CH. Variations in the AURKA Gene: Biomarkers for the Development and Progression of Hepatocellular Carcinoma. Int J Med Sci 2018; 15(2):170-175. doi:10.7150/ijms.22513. https://www.medsci.org/v15p0170.htm

CSE
Wang B, Hsu CJ, Chou CH, Lee HL, Chiang WL, Su CM, Tsai HC, Yang SF, Tang CH. 2018. Variations in the AURKA Gene: Biomarkers for the Development and Progression of Hepatocellular Carcinoma. Int J Med Sci. 15(2):170-175.

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