International Journal of Medical Sciences

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22 November 2017

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Int J Med Sci 2017; 14(13):1360-1367. doi:10.7150/ijms.17367

Research Paper

Over-expression of Activated Signal Transducer and Activator of Transcription 3 Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma

Wei-Ming Li1,2,3,4, Chun-Nung Huang1,2,3,5, Yi-Chen Lee2,6, Szu-Han Chen1,2, Hui-Hui Lin1,3, Wen-Jeng Wu1,2,3,5,7,8, Ching-Chia Li 1,2,3,8, Hsin-Chih Yeh1,2,3,5,8, Lin-Li Chang2,9, Wei-Chi Hsu1,2,3, Hung-Lung Ke1,2,3✉

1. Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
2. Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
3. Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
4. Department of Urology, Ministry of Health and Welfare Pingtung Hospital, Pingtung, Taiwan
5. Center for Infectious Disease and Cancer Research, Kaohsiung Medical University, Kaohsiung, Taiwan
6. Department of Anatomy, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
7. Center for Stem Cell Research, Kaohsiung Medical University, Kaohsiung, Taiwan
8. Department of Urology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan
9. Department of Microbiology, Kaohsiung Medical University, Kaohsiung, Taiwan

Abstract

Background: Signal transducer and activator of transcription proteins (STATs) play important roles in gene regulation, cell proliferation, and cell differentiation. We aimed to establish the relationship between phosphorylated STAT3 (p-Ser-STAT3) expression and the prognosis of upper tract urothelial carcinoma (UTUC).

Methods: This study retrospectively reviewed 100 patients with pathologically confirmed UTUC at Kaohsiung Medical University Hospital. We quantified the expression of p-Ser-STAT3 in cancer cells by immunohistochemistry, and determined the clinicopathological significance of p-Ser-STAT3 expression and prognostic outcomes in patients with UTUC.

Results: High p-Ser-STAT3 expression was detected in 52% of UTUC patients. High p-Ser-STAT3 expression was associated with poor recurrence-free survival (p = 0.018) and overall survival (p = 0.026). In advanced cancer samples (stage T3/T4), p-Ser-STAT3 expression is the only independent prognostic factor for recurrence-free survival (hazard ratio = 5.91, p = 0.01) and cancer-specific survival (hazard ratio = 8.83, p = 0.039).

Conclusions: The expression of p-Ser-STAT3 can be a potential prognostic marker for cancer recurrence and survival in UTUC, especially in advanced stage cases.

Keywords: Upper tract urothelial carcinoma, signal transducer and activator of transcription 3, immunohistochemistry, prognosis

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Li WM, Huang CN, Lee YC, Chen SH, Lin HH, Wu WJ, Li CC, Yeh HC, Chang LL, Hsu WC, Ke HL. Over-expression of Activated Signal Transducer and Activator of Transcription 3 Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma. Int J Med Sci 2017; 14(13):1360-1367. doi:10.7150/ijms.17367. Available from http://www.medsci.org/v14p1360.htm