International Journal of Medical Sciences

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22 November 2017

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Int J Med Sci 2017; 14(13):1342-1359. doi:10.7150/ijms.21875

Review

Peptides as Therapeutic Agents for Dengue Virus

Miaw-Fang Chew1, Keat-Seong Poh2, Chit-Laa Poh1✉

1. Research Centre for Biomedical Sciences, Sunway University, Bandar Sunway, Selangor 47500, Malaysia;
2. Department of Surgery, Faculty of Medicine, University of Malaya, Jalan Universiti, Kuala Lumpur, 50603, Malaysia.

Abstract

Dengue is an important global threat caused by dengue virus (DENV) that records an estimated 390 million infections annually. Despite the availability of CYD-TDV as a commercial vaccine, its long-term efficacy against all four dengue virus serotypes remains unsatisfactory. There is therefore an urgent need for the development of antiviral drugs for the treatment of dengue. Peptide was once a neglected choice of medical treatment but it has lately regained interest from the pharmaceutical industry following pioneering advancements in technology. In this review, the design of peptide drugs, antiviral activities and mechanisms of peptides and peptidomimetics (modified peptides) action against dengue virus are discussed. The development of peptides as inhibitors for viral entry, replication and translation is also described, with a focus on the three main targets, namely, the host cell receptors, viral structural proteins and viral non-structural proteins. The antiviral peptides designed based on these approaches may lead to the discovery of novel anti-DENV therapeutics that can treat dengue patients.

Keywords: Dengue virus, Drug discovery, Peptides, Antiviral therapeutics.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Chew MF, Poh KS, Poh CL. Peptides as Therapeutic Agents for Dengue Virus. Int J Med Sci 2017; 14(13):1342-1359. doi:10.7150/ijms.21875. Available from http://www.medsci.org/v14p1342.htm