Int J Med Sci 2017; 14(11):1110-1117. doi:10.7150/ijms.20547
Effect of Coriolus versicolor Mycelia Extract on Exercise Performance and Physical Fatigue in Mice
1. Division of Physical Medicine and Rehabilitation, Lo-Hsu Foundation, Inc., Lotung Poh-Ai Hospital, Yilan 26546, Taiwan;
2. College of Exercise and Health Sciences, National Taiwan Sport University, Taoyuan 33301, Taiwan;
3. Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei 11031, Taiwan;
4. Department of Neurosurgery, Lo-Hsu Foundation, Inc., Lotung Poh-Ai Hospital, Yilan 26546, Taiwan; Department of Exercise and Health Promotion, College of Education, Chinese Culture University, Taipei 11114, Taiwan;
5. Graduate Institute of Athletics and Coaching Science, National Taiwan Sport University, Taoyuan 33301, Taiwan;
6. Department of Forestry, National Chung Hsing University, Taichung 40227, Taiwan.
* These authors contributed equally to this work.
In this study, Coriolus versicolor mycelia (CVM) was evaluated the ergogenic and anti-fatigue activities. Male ICR mice were divided into four groups (n = 8/group) to receive vehicle or CVM by oral gavage for 4 weeks at 0, 615, 1230 or 3075 mg/kg/day, which were respectively designated the vehicle, CVM-1X, CVM-2X and CVM-5X groups. Forelimb grip strength, endurance swimming time, and levels of physical fatigue-associated parameters serum lactate, ammonia, glucose and creatine kinase (CK) after physical challenge were performed to evaluate exercise performance and anti-fatigue activity. Results revealed that the forelimb grip strength of mice in group CVM-1X, CVM-2X and CVM-5X were significantly increased by 1.20-, 1.18- and 1.23-fold, respectively, compared to the vehicle group. After the 15 minute swimming exercise, the levels of serum lactate of CVM-1X, CVM-2X and CVM-5X groups were significantly lower than the vehicle control group by 29%, 23% and 31%, respectively. The levels of ammonia in CVM-1X, CVM-2X and CVM-5X groups were significantly lowered by 22%, 25% and 41%, respectively, compared to the vehicle control group. In addition, the levels of serum CK in CVM-2X and CVM-5X groups were significantly lowered by 13% and 11%, respectively, compared to the vehicle control group. Accordingly, the supplementation with CVM has beneficial effects on performance improvement and anti-fatigue activity, and thus has great potential as a source for natural health products.
Keywords: Coriolus versicolor, mycelia, polysaccharopeptide, anti-fatigue, exercise performance.
Ho CS, Tung YT, Kung WM, Huang WC, Leung WK, Huang CC, Wu JH. Effect of Coriolus versicolor Mycelia Extract on Exercise Performance and Physical Fatigue in Mice. Int J Med Sci 2017; 14(11):1110-1117. doi:10.7150/ijms.20547. Available from http://www.medsci.org/v14p1110.htm