22 May 2018
Int J Med Sci 2017; 14(11):1110-1117. doi:10.7150/ijms.20547
Effect of Coriolus versicolor Mycelia Extract on Exercise Performance and Physical Fatigue in Mice
1. Division of Physical Medicine and Rehabilitation, Lo-Hsu Foundation, Inc., Lotung Poh-Ai Hospital, Yilan 26546, Taiwan;
In this study, Coriolus versicolor mycelia (CVM) was evaluated the ergogenic and anti-fatigue activities. Male ICR mice were divided into four groups (n = 8/group) to receive vehicle or CVM by oral gavage for 4 weeks at 0, 615, 1230 or 3075 mg/kg/day, which were respectively designated the vehicle, CVM-1X, CVM-2X and CVM-5X groups. Forelimb grip strength, endurance swimming time, and levels of physical fatigue-associated parameters serum lactate, ammonia, glucose and creatine kinase (CK) after physical challenge were performed to evaluate exercise performance and anti-fatigue activity. Results revealed that the forelimb grip strength of mice in group CVM-1X, CVM-2X and CVM-5X were significantly increased by 1.20-, 1.18- and 1.23-fold, respectively, compared to the vehicle group. After the 15 minute swimming exercise, the levels of serum lactate of CVM-1X, CVM-2X and CVM-5X groups were significantly lower than the vehicle control group by 29%, 23% and 31%, respectively. The levels of ammonia in CVM-1X, CVM-2X and CVM-5X groups were significantly lowered by 22%, 25% and 41%, respectively, compared to the vehicle control group. In addition, the levels of serum CK in CVM-2X and CVM-5X groups were significantly lowered by 13% and 11%, respectively, compared to the vehicle control group. Accordingly, the supplementation with CVM has beneficial effects on performance improvement and anti-fatigue activity, and thus has great potential as a source for natural health products.
Keywords: Coriolus versicolor, mycelia, polysaccharopeptide, anti-fatigue, exercise performance.
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How to cite this article:
Ho CS, Tung YT, Kung WM, Huang WC, Leung WK, Huang CC, Wu JH. Effect of Coriolus versicolor Mycelia Extract on Exercise Performance and Physical Fatigue in Mice. Int J Med Sci 2017; 14(11):1110-1117. doi:10.7150/ijms.20547. Available from http://www.medsci.org/v14p1110.htm