16 August 2018
Global reach, higher impact
Int J Med Sci 2017; 14(8):705-710. doi:10.7150/ijms.19018
Characterization and Prospective of Human Corneal Endothelial Progenitors
1. Department of Ophthalmology, Yan' An Hospital of Kunming City, Kunming, 650051, China;
Corneal endothelial cells play a critical role in maintaining corneal transparency and dysfunction of these cells caused by aging, diseases (such as Fuch's dystrophy), injury or surgical trauma, which can lead to corneal edema and blindness. Due to their limited proliferative capacity in vivo, the only treatment method is via transplantation of a cadaver donor cornea. However, there is a severe global shortage of donor corneas. To circumvent such issues, tissue engineering of corneal tissue is a viable option thanks to the recent discoveries in this field. In this review, we summarize the recent advances in reprogramming adult human corneal endothelial cells into their progenitor status, the expansion methods and characteristics of human corneal endothelial progenitors, and their potential clinical applications as corneal endothelial cell grafts.
Keywords: Cornea, Endothelial, Progenitors, Tissue Engineering.
This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Liu Y, Sun H, Guo P, Hu M, Zhang Y, Tighe S, Chen S, Zhu Y. Characterization and Prospective of Human Corneal Endothelial Progenitors. Int J Med Sci 2017; 14(8):705-710. doi:10.7150/ijms.19018. Available from http://www.medsci.org/v14p0705.htm