Hypoxia-regulated MicroRNA-210 Overexpression is Associated with Tumor Development and Progression in Upper Tract Urothelial Carcinoma

Ke, Hung-Lung; Li, Wei-Ming; Lin, Hui-Hui; Hsu, Wei-Chi; Hsu, Ya-Ling; Chang, Lin-Li; Huang, Chun-Nung; Li, Ching-Chia; Chang, Hsin-Ping; Yeh, Hsin-Chih; Li, Chien-Feng; Wu, Wen-Jeng

doi:10.7150/ijms.15699

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Int J Med Sci 2017; 14(6):578-584. doi:10.7150/ijms.15699 This issue Cite

Research Paper

Hypoxia-regulated MicroRNA-210 Overexpression is Associated with Tumor Development and Progression in Upper Tract Urothelial Carcinoma

Hung-Lung Ke^1,2,3, Wei-Ming Li^1,2,3,4, Hui-Hui Lin^2,3, Wei-Chi Hsu^1,2,3, Ya-Ling Hsu¹, Lin-Li Chang^1,6, Chun-Nung Huang^1,2,3, Ching-Chia Li^2,3,5, Hsin-Ping Chang^2,3, Hsin-Chih Yeh^1,2,3, Chien-Feng Li^7,8,9, Wen-Jeng Wu^1,2,3,5✉

1. Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
2. Department of Urology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
3. Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;
4. Department of Urology, Ministry of Health and Welfare Pingtung Hospital, Pingtung, Taiwan;
5. Department of Urology, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan;
6. Department of Microbiology, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
7. Department of Pathology, Chi Mei Medical Center, Tainan, Taiwan;
8. National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan;
9. Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan, Taiwan.

Citation:

Ke HL, Li WM, Lin HH, Hsu WC, Hsu YL, Chang LL, Huang CN, Li CC, Chang HP, Yeh HC, Li CF, Wu WJ. Hypoxia-regulated MicroRNA-210 Overexpression is Associated with Tumor Development and Progression in Upper Tract Urothelial Carcinoma. Int J Med Sci 2017; 14(6):578-584. doi:10.7150/ijms.15699. https://www.medsci.org/v14p0578.htm

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Abstract

Background: Hypoxia has been shown to facilitate tumor progression. Hypoxia-regulated microRNA-210 (miR-210) may play an important role in carcinogenesis and tumor progression. In this study, we evaluated the clinical significance of miR-210 expression in upper tract urothelial carcinoma (UTUC).

Methods: Eighty-three UTUC patients participated in this study. All of them provided cancer tissue samples and 50 of them provided non-cancerous urothelium samples. Clinicopathologic data were collected by reviewing medical records. The expression of miR-210 and hypoxia-inducible factor-1α (HIF-1α) was determined by quantitative real-time polymerase chain reaction. The relationship between clinicopathologic variables and the expression of miR-210 and HIF-1α was analyzed statistically.

Results: MiR-210 is overexpressed in UTUC compared to non-cancerous urothelium (p < 0.001); it is also upregulated in high-stage and high-grade tumors (p = 0.020 and 0.049, respectively). HIF-1α is overexpressed in UTUC and correlates positively with miR-210 expression (r = 0.442, p = 0.001).

Conclusion: Both miR-210 and HIF-1α are involved in promoting UTUC carcinogenesis. MiR-210 is also correlated with tumor progression. Further studies are needed to clarify the underlying mechanism.

Keywords: Upper tract urothelial carcinoma, HIF-1α, miR-210.

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APA

Ke, H.L., Li, W.M., Lin, H.H., Hsu, W.C., Hsu, Y.L., Chang, L.L., Huang, C.N., Li, C.C., Chang, H.P., Yeh, H.C., Li, C.F., Wu, W.J. (2017). Hypoxia-regulated MicroRNA-210 Overexpression is Associated with Tumor Development and Progression in Upper Tract Urothelial Carcinoma. International Journal of Medical Sciences, 14(6), 578-584. https://doi.org/10.7150/ijms.15699.

ACS

Ke, H.L.; Li, W.M.; Lin, H.H.; Hsu, W.C.; Hsu, Y.L.; Chang, L.L.; Huang, C.N.; Li, C.C.; Chang, H.P.; Yeh, H.C.; Li, C.F.; Wu, W.J. Hypoxia-regulated MicroRNA-210 Overexpression is Associated with Tumor Development and Progression in Upper Tract Urothelial Carcinoma. Int. J. Med. Sci. 2017, 14 (6), 578-584. DOI: 10.7150/ijms.15699.

NLM

CSE

Ke HL, Li WM, Lin HH, Hsu WC, Hsu YL, Chang LL, Huang CN, Li CC, Chang HP, Yeh HC, Li CF, Wu WJ. 2017. Hypoxia-regulated MicroRNA-210 Overexpression is Associated with Tumor Development and Progression in Upper Tract Urothelial Carcinoma. Int J Med Sci. 14(6):578-584.

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