International Journal of Medical Sciences

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17 October 2017

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Int J Med Sci 2017; 14(6):543-553. doi:10.7150/ijms.18988

Research Paper

Existence of a Strong Correlation of Biomarkers and miRNA in Females with Metabolic Syndrome and Obesity in a Population of West Virginia

Perrine Goguet-Rubio1*, Rebecca L. Klug2*, Dana L. Sharma1, Krithika Srikanthan1, Nitin Puri3, Vishal H Lakhani1, Alexandra Nichols1, Kathleen M. O'Hanlon4, Nader G. Abraham5, Joseph I. Shapiro1, Komal Sodhi2✉

1. Department of Internal Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA;
2. Department of Surgery, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA;
3. Department of Physiology & Pharmacology, University of Toledo College of Medicine, Toledo OH, USA;
4. Department of Family Medicine, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA;
5. Department of Pharmacology and Medicine, New York Medical College, The Touro College and University System, Valhalla, NY, USA.
* Both authors contributed equally

Abstract

Objectives: Metabolic syndrome causes complications like cardiovascular disease and type 2 diabetes mellitus (T2DM). As metabolic syndrome develops, altered levels of cytokines and microRNAs (miRNA) are measurable in the circulation. We aimed to construct a panel detecting abnormal levels of cytokines and miRNAs in patients at risk for metabolic syndrome. Methods: Participants included 54 patients from a Family Medicine Clinic at Marshall University School of Medicine, in groups of: Control, Obese, and Metabolic Syndrome (MetS). Results: Serum levels of leptin, adiponectin, leptin: adiponectin ratio, IL-6, six miRNAs (320a, 197-3p, 23-3p, 221-3p, 27a-3p, and 130a-3p), were measured. Among the three groups, leptin, and leptin: adiponectin ratio, and IL-6 levels were highest in MetS, and levels in Obese were greater than Control (p>0.05). Adiponectin levels were lower in Obese compared to Control, but lowest in MetS (p<0.05). MiRNAs levels were lowest in MetS, and levels in Obese were lower than Control (p>0.05). Conclusion: Our results support the clinical application of biomarkers in diagnosing early stage MetS, which will enable attenuation of disease progression before onset of irreversible complications. Since West Virginians are high-risk for developing MetS, our biomarker panel could reduce the disease burden on our population.

Keywords: metabolic syndrome, microRNA, serum biomarkers, West Virginia.

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How to cite this article:
Goguet-Rubio P, Klug RL, Sharma DL, Srikanthan K, Puri N, Lakhani VH, Nichols A, O'Hanlon KM, Abraham NG, Shapiro JI, Sodhi K. Existence of a Strong Correlation of Biomarkers and miRNA in Females with Metabolic Syndrome and Obesity in a Population of West Virginia. Int J Med Sci 2017; 14(6):543-553. doi:10.7150/ijms.18988. Available from http://www.medsci.org/v14p0543.htm