Int J Med Sci 2016; 13(9):696-700. doi:10.7150/ijms.16259

Research Paper

Prognostic Value of Prostaglandin-endoperoxide Synthase 2 Polymorphisms in Prostate Cancer Recurrence after Radical Prostatectomy

Cheng-Hsueh Lee1,2, Jiunn-Bey Pao3, Te-Ling Lu4, Hong-Zin Lee4, Yung-Chin Lee1,5, Chia-Chu Liu1,5, Chao-Yuan Huang6, Victor C. Lin7,8, Chia-Cheng Yu9,10, Hsin-Ling Yin11,12, Shu-Pin Huang1,2,5✉, Bo-Ying Bao4,13,14✉

1. Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;
2. Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
3. Department of Pharmacy, Linsen Chinese Medicine Branch, Taipei City Hospital, Taipei, Taiwan;
4. Department of Pharmacy, China Medical University, Taichung, Taiwan;
5. Department of Urology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;
6. Department of Urology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan;
7. Department of Urology, E-Da Hospital, Kaohsiung, Taiwan;
8. School of Medicine for International Students, I-Shou University, Kaohsiung, Taiwan;
9. Division of Urology, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan;
10. Department of Urology, School of Medicine, National Yang-Ming University, Taipei, Taiwan;
11. Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;
12. Department of Pathology, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
13. Sex Hormone Research Center, China Medical University Hospital, Taichung, Taiwan;
14. Department of Nursing, Asia University, Taichung, Taiwan.

Abstract

Backgroud: Increasing evidence suggests the involvement of chronic inflammation in the progression of prostate cancer, and prostaglandin-endoperoxide synthase 2 (PTGS2), also known as cyclooxygenase-2, catalyzes the rate-limiting steps of the pathway. We hypothesized that genetic variants of PTGS2 can influence the outcome of prostate cancer patients.

Methods: We genotyped five haplotype-tagging single-nucleotide polymorphisms (SNPs) to detect common genetic variations across the PTGS2 region in 458 prostate cancer patients treated with radical prostatectomy.

Results: One SNP, rs4648302, was associated with disease recurrence. Five-year recurrence-free survival rate increased according to the number of variant alleles inherited (55.6%, 70.7%, and 100.0% for patients with different genotypes; P = 0.037), and the effect was maintained in multivariable analysis. Public dataset analyses also suggested that PTGS2 expression was correlated with prostate cancer prognosis.

Conclusion: Our results indicated that PTGS2 could be a potential prognostic marker to improve the prediction of disease recurrence in prostate cancer patients.

Keywords: biochemical recurrence, prostate cancer, radical prostatectomy, single-nucleotide polymorphism, PTGS2, inflammation.

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How to cite this article:
Lee CH, Pao JB, Lu TL, Lee HZ, Lee YC, Liu CC, Huang CY, Lin VC, Yu CC, Yin HL, Huang SP, Bao BY. Prognostic Value of Prostaglandin-endoperoxide Synthase 2 Polymorphisms in Prostate Cancer Recurrence after Radical Prostatectomy. Int J Med Sci 2016; 13(9):696-700. doi:10.7150/ijms.16259. Available from http://www.medsci.org/v13p0696.htm