International Journal of Medical Sciences

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17 October 2017

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Int J Med Sci 2016; 13(9):673-679. doi:10.7150/ijms.16175

Research Paper

Utility of Plasma Osteopontin Levels in Management of Community-Acquired Pneumonia

Jer-Hwa Chang1,2, Wen-Yueh Hung3, Kuan-Jen Bai1,2, Shun-Fa Yang4,5✉, Ming-Hsien Chien6,7✉

1. Division of Pulmonary Medicine, Department of Internal Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan;
2. School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan;
3. Division of Pulmonary Medicine, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan;
4. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan;
5. Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan;
6. Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan;
7. Department of Medical Education and Research, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan.

Abstract

Osteopontin (OPN) is an essential cytokine involved in immune cell recruitment and an important regulator of inflammation. The purpose of this study was to examine differences in OPN plasma levels between before and after antibiotic treatment in hospitalized adult patients with community-acquired pneumonia (CAP). OPN levels were measured in 93 patients with CAP and 54 healthy controls using a commercial enzyme-linked immunosorbent assay (ELISA). The CURB-65, Pneumonia Severity Index (PSI), and Acute Physiology and Chronic Health Evaluation II (APACHE II) scores were used to determine the CAP severity in patients upon initial hospitalization. A decline in the number of white blood cells (WBCs) and neutrophils, and decreases in the levels of OPN and C-reactive protein (CRP) were observed after antibiotic treatment. Only the plasma level of OPN, but not CRP, was correlated with the severity of CAP based on the PSI (r = 0.514, p < 0.001), CURB-65 (r = 0.396, p < 0.001), and APACHE II scores (r = 0.473, p < 0.001). The OPN level also showed a significant correlation with the length of hospital stay (r = 0.210, p = 0.044). In conclusion, plasma level of OPN may act as diagnostic adjuvant biomarkers for CAP and further play a role in clinical assessment of the severity of CAP, which could potentially guide the development of treatment strategies.

Keywords: Biochemical marker, Community-acquired pneumonia, Osteopontin, Pneumonia Severity Index.

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How to cite this article:
Chang JH, Hung WY, Bai KJ, Yang SF, Chien MH. Utility of Plasma Osteopontin Levels in Management of Community-Acquired Pneumonia. Int J Med Sci 2016; 13(9):673-679. doi:10.7150/ijms.16175. Available from http://www.medsci.org/v13p0673.htm