International Journal of Medical Sciences

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13 December 2017

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Int J Med Sci 2016; 13(3):187-194. doi:10.7150/ijms.14246

Research Paper

A Prospective Randomized Experimental Study to Investigate the Eradication Rate of Endometriosis after Surgical Resection versus Aerosol Plasma Coagulation in a Rat Model

Ralf Rothmund1, Marcus Scharpf2, Christos Tsaousidis1, Constanze Planck1, Markus Dominik Enderle3, Alexander Neugebauer3, Kristin Kroeker3, Daniela Nuessle3, Falko Fend2, Sara Brucker1, Bernhard Kraemer1 ✉

1. Department of Obstetrics and Gynaecology, University of Tuebingen, Calwerstr. 7, 72076 Tuebingen, Germany (Director: Prof. D. Wallwiener);
2. Department of Pathology, University of Tuebingen, Liebermeisterstr. 8, 72076 Tuebingen, Germany (Director: Prof. F. Fend);
3. Erbe Elektromedizin GmbH, Waldhoernlestr. 17, 72072 Tuebingen, Germany.

Abstract

Purpose To investigate the eradication rate of endometriosis after surgical resection (SR) vs. thermal ablation with aerosol plasma coagulation (AePC) in a rat model.

Methods In this prospective, randomized, controlled, single-blinded animal study endometriosis was induced on the abdominal wall of 34 female Wistar rats. After 14 days endometriosis was either removed by SR or ablated by AePC. 14 days later the rats were euthanized to evaluate the eradication rate histopathologically. Intervention times were recorded.

Results Eradication rate of endometriosis after 14 days did not significantly differ between AePC and SR (p=0.22). Intervention time per endometrial lesion was 22.1 s for AePC and 51.8 s for SR (p<0.0001).

Conclusions This study compares the eradication rate of the new aerosol plasma coagulation device versus standard surgical resection of endometriosis in a rat model. Despite being a thermal method, AePC showed equality towards SR regarding eradication rate but with significantly shorter intervention time.

Keywords: aerosol plasma coagulation, endometriosis, rat model, non-contact method, thermal damage.

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How to cite this article:
Rothmund R, Scharpf M, Tsaousidis C, Planck C, Enderle MD, Neugebauer A, Kroeker K, Nuessle D, Fend F, Brucker S, Kraemer B. A Prospective Randomized Experimental Study to Investigate the Eradication Rate of Endometriosis after Surgical Resection versus Aerosol Plasma Coagulation in a Rat Model. Int J Med Sci 2016; 13(3):187-194. doi:10.7150/ijms.14246. Available from http://www.medsci.org/v13p0187.htm