Full Text | PDF

Share on tweeters Share on facebook Share on linkedin Share on googleplus

Int J Med Sci 2015; 12(8):668-673. doi:10.7150/ijms.12233 This issue Cite

Research Paper

The Association of BCG Vaccination with Atopy and Asthma in Adults

Sung Soo Park1, Eun Young Heo1, Deog Kyeom Kim1, Hee Soon Chung1, Chang-Hoon Lee1,2✉

1. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical center, Seoul, Republic of Korea
2. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea

✉ Corresponding author: Chang-Hoon Lee, MD. Current address: Associate professor, Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, 101 More

Citation:
Park SS, Heo EY, Kim DK, Chung HS, Lee CH. The Association of BCG Vaccination with Atopy and Asthma in Adults. Int J Med Sci 2015; 12(8):668-673. doi:10.7150/ijms.12233. https://www.medsci.org/v12p0668.htm
Other styles

File import instruction

Abstract

Introduction: There are few studies investigating the association between BCG vaccination and atopy or asthma in adults.

Objective: We investigated the association between BCG scar and the occurrence of atopy and asthma in Korean adults.

Methods: We carried out a retrospective study of Korean adults who underwent skin prick testing, and, in some cases, spirometry and bronchial provocation tests in a secondary care hospital from April 2010 to February 2011. Atopy status was classified according to allergen/histamine (A/H) ratio of wheal (A/H ratio ≥ 1, atopy; 0 < A/H ratio < 1, intermediate; A/H ratio = 0, non-atopy). A patient with asthma was defined as one who has symptoms compatible with asthma and showed either a positive provocation testing or bronchodilator reversibility.

Results: Among 200 participants, neither the presence (intermediate vs. non-atopy: adjusted odds ratio (aOR) 0.83; 95% CI 0.26, 2.60; p = 0.75, atopy vs. non-atopy: aOR 0.89; 95% CI 0.33, 2.37; p = 0.81, respectively). nor the size of BCG scar was significantly associated with atopy status. However, among those patients who underwent either bronchodilator response testing or bronchial provocation testing, the presence of BCG scar (aOR 0.33; CI 0.14, 0.77; p = 0.01) and the size of BCG scar were inversely associated with asthma. (p = 0.01)

Conclusions: We found a significant association between BCG scar and asthmatic status in Korean adults, although there was no significant association between either the presence or size of BCG scar and atopy.

Keywords: BCG vaccine, atopy, asthma, hygiene

Citation styles

APA
Park, S.S., Heo, E.Y., Kim, D.K., Chung, H.S., Lee, C.H. (2015). The Association of BCG Vaccination with Atopy and Asthma in Adults. International Journal of Medical Sciences, 12(8), 668-673. https://doi.org/10.7150/ijms.12233.

ACS
Park, S.S.; Heo, E.Y.; Kim, D.K.; Chung, H.S.; Lee, C.H. The Association of BCG Vaccination with Atopy and Asthma in Adults. Int. J. Med. Sci. 2015, 12 (8), 668-673. DOI: 10.7150/ijms.12233.

NLM
Park SS, Heo EY, Kim DK, Chung HS, Lee CH. The Association of BCG Vaccination with Atopy and Asthma in Adults. Int J Med Sci 2015; 12(8):668-673. doi:10.7150/ijms.12233. https://www.medsci.org/v12p0668.htm

CSE
Park SS, Heo EY, Kim DK, Chung HS, Lee CH. 2015. The Association of BCG Vaccination with Atopy and Asthma in Adults. Int J Med Sci. 12(8):668-673.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
Popup Image

©2024 Ivyspring International Publisher. Terms of use