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Int J Med Sci 2015; 12(6):517-523. doi:10.7150/ijms.11376 This issue Cite

Research Paper

Comparison of Drug Concentrations in Human Aqueous Humor after the Administration of 0.3% Gatifloxacin Ophthalmic Gel, 0.3% Gatifloxacin and 0.5% Levofloxacin Ophthalmic Solutions

Wenting Ding1, Weiling Ni1, Huilian Chen1, Jingqun Yuan2, Xiaodan Huang1, Zheng Zhang1, Yao Wang1, Yibo Yu1, Ke Yao1✉

1. From the Eye Center, Affiliated Second Hospital, College of Medicine, Zhejiang University, Hangzhou, China
2. Analysis Centre of Agrobiology and Environmental Sciences, Zhejiang University, Hangzhou, China

✉ Corresponding author: Ke Yao, MD, Eye Center, Affiliated Second Hospital, College of Medicine, Zhejiang University, Hangzhou, 310009, China. E-mail: xlrenedu.cn.

Citation:
Ding W, Ni W, Chen H, Yuan J, Huang X, Zhang Z, Wang Y, Yu Y, Yao K. Comparison of Drug Concentrations in Human Aqueous Humor after the Administration of 0.3% Gatifloxacin Ophthalmic Gel, 0.3% Gatifloxacin and 0.5% Levofloxacin Ophthalmic Solutions. Int J Med Sci 2015; 12(6):517-523. doi:10.7150/ijms.11376. https://www.medsci.org/v12p0517.htm
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Abstract

Purpose: To investigate the penetration of 0.3% gatifloxacin ophthalmic gel, 0.3% gatifloxacin ophthalmic solution and 0.5% levofloxacin ophthalmic solution into aqueous humor after topical application.

Materials and Methods: Age-related cataract patients (150 eyes in 150 cases) receiving phacoemulsification were randomly divided into three groups: a 0.3% gatifloxacin gel group (n=50), a 0.3% gatifloxacin solution group (n=50), and a 0.5% levofloxacin solution group (n=50). Each group was administered one drop of gel or solution every 15 minutes for four doses. Aqueous samples were collected at different time points after the last drop. High pressure liquid chromatography (HPLC) was applied to determine the concentrations. The one-way ANOVA analysis was performed.

Results: Our data indicated that the concentration of the gatifloxacin gel group was higher than that of the gatifloxacin solution group at all time points (P <0.05); moreover, the gatifloxacin gel group exhibited higher levels than the levofloxacin solution group at 120.0 min and 180.0 min (P<0.05). Furthermore, the gatifloxacin gel produced the highest concentration at 120.0 min, and the gatifloxacin and levofloxacin solutions reached their peak values at 60.0 min.

Conclusions: 0.3% gatifloxacin ophthalmic gel application produced highest aqueous humor drug concentration, maintained the longest time, had the best penetration and bioavailability.

Keywords: aqueous humor, levofloxacin, gatifloxacin, ophthalmic gel, ophthalmic solution

Citation styles

APA
Ding, W., Ni, W., Chen, H., Yuan, J., Huang, X., Zhang, Z., Wang, Y., Yu, Y., Yao, K. (2015). Comparison of Drug Concentrations in Human Aqueous Humor after the Administration of 0.3% Gatifloxacin Ophthalmic Gel, 0.3% Gatifloxacin and 0.5% Levofloxacin Ophthalmic Solutions. International Journal of Medical Sciences, 12(6), 517-523. https://doi.org/10.7150/ijms.11376.

ACS
Ding, W.; Ni, W.; Chen, H.; Yuan, J.; Huang, X.; Zhang, Z.; Wang, Y.; Yu, Y.; Yao, K. Comparison of Drug Concentrations in Human Aqueous Humor after the Administration of 0.3% Gatifloxacin Ophthalmic Gel, 0.3% Gatifloxacin and 0.5% Levofloxacin Ophthalmic Solutions. Int. J. Med. Sci. 2015, 12 (6), 517-523. DOI: 10.7150/ijms.11376.

NLM
Ding W, Ni W, Chen H, Yuan J, Huang X, Zhang Z, Wang Y, Yu Y, Yao K. Comparison of Drug Concentrations in Human Aqueous Humor after the Administration of 0.3% Gatifloxacin Ophthalmic Gel, 0.3% Gatifloxacin and 0.5% Levofloxacin Ophthalmic Solutions. Int J Med Sci 2015; 12(6):517-523. doi:10.7150/ijms.11376. https://www.medsci.org/v12p0517.htm

CSE
Ding W, Ni W, Chen H, Yuan J, Huang X, Zhang Z, Wang Y, Yu Y, Yao K. 2015. Comparison of Drug Concentrations in Human Aqueous Humor after the Administration of 0.3% Gatifloxacin Ophthalmic Gel, 0.3% Gatifloxacin and 0.5% Levofloxacin Ophthalmic Solutions. Int J Med Sci. 12(6):517-523.

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