International Journal of Medical Sciences

Impact factor
2.399

19 October 2017

ISSN 1449-1907 News feeds of published articles

My Manuscript | My Account

Journal of Genomics now in PubMed/PubMed Central. Submit manuscript...

Journal of Biomedicinenew

Theranostics

Journal of Cancer

Oncomedicine

International Journal of Biological Sciences

Journal of Genomics

Journal of Bone and Joint Infection (JBJI)

Nanotheranostics

PubMed Central Indexed in Journal Impact Factor

Int J Med Sci 2015; 12(6):487-493. doi:10.7150/ijms.10982

Research Paper

Pim-2 Modulates Aerobic Glycolysis and Energy Production during the Development of Colorectal Tumors

Xue-hui Zhang1, Hong-liang Yu1,2, Fu-jing Wang2, Yong-long Han3, Wei-liang Yang2✉

1. Daqing Oilfield General Hospital, Zhongkang Street 9, Daqing, 163001, China
2. The Second Affiliated Hospital of Harbin Medical University, Road Xuefu 246, Harbin, 150086, China
3. The Sixth People's Affiliated Hospital of Shanghai Jiao Tong University, Road Yishan 600, Shanghai, 200233, China

Abstract

Tumor cells have higher rates of glucose uptake and aerobic glycolysis to meet energy demands for proliferation and metastasis. The characteristics of increased glucose uptake, accompanied with aerobic glycolysis, has been exploited for the diagnosis of cancers. Although much progress has been made, the mechanisms regulating tumor aerobic glycolysis and energy production are still not fully understood. Here, we demonstrate that Pim-2 is required for glycolysis and energy production in colorectal tumor cells. Our results show that Pim-2 is highly expressed in colorectal tumor cells, and may be induced by nutrient stimulation. Activation of Pim-2 in colorectal cells led to increase glucose utilization and aerobic glycolysis, as well as energy production. While knockdown of Pim-2 decreased energy production in colorectal tumor cells and increased their susceptibility to apoptosis. Moreover, the effects of Pim-2 kinase on aerobic glycolysis seem to be partly dependent on mTORC1 signaling, because inhibition of mTORC1 activity reversed the aerobic glycolysis mediated by Pim-2. Our findings suggest that Pim-2-mediated aerobic glycolysis is critical for monitoring Warburg effect in colorectal tumor cells, highlighting Pim-2 as a potential metabolic target for colorectal tumor therapy.

Keywords: Pim-2, Aerobic glycolysis, Apoptosis, Warburg effect

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Zhang Xh, Yu Hl, Wang Fj, Han Yl, Yang Wl. Pim-2 Modulates Aerobic Glycolysis and Energy Production during the Development of Colorectal Tumors. Int J Med Sci 2015; 12(6):487-493. doi:10.7150/ijms.10982. Available from http://www.medsci.org/v12p0487.htm