International Journal of Medical Sciences

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18 December 2017

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Int J Med Sci 2014; 11(11):1098-1106. doi:10.7150/ijms.8083

Research Paper

Comparison the Prognostic Value of Galectin-3 and Serum Markers of Cardiac Extracellular Matrix Turnover in Patients with Chronic Systolic Heart Failure

Yi-Yao Chang1, Aaron Chen2, Xue-Ming Wu3, Tse-Pin Hsu4, Li-Yu Daisy Liu6, Yenh-Hsein Chen4, Yen-Wen Wu1,7, Hung-Ju Lin4, Ron-Bin Hsu5, Chi-Ming Lee4, Shoei-Shen Wang5, Men-Tzung Lo8, Ming-Fong Chen4, Yen-Hung Lin4✉

1. Cardiology Division of Cardiovascular Medical Center, Far Eastern Memorial Hospital, New Taipei City, Taiwan;
2. Woodhull Medical and Mental Hospital, Brooklyn, New York, USA;
3. Department of Internal Medicine, Taoyuan General Hospital, Taoyuan, Taiwan;
4. Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan;
5. Department of Surgery, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan;
6. Department of Agronomy, Biometry Division, National Taiwan University, Taipei, Taiwan;
7. National Yang-Ming University School of Medicine, Taipei, Taiwan;
8. Center for Dynamical Biomarkers and Translational Medicine, National Central University, Chungli, Taiwan.

Abstract

Background: Galectin-3 (Gal-3) shows the ability of survival prediction in heart failure (HF) patients. However, Gal-3 is strongly associated with serum markers of cardiac extracellular matrix (ECM) turnover. The aim of this study is to compare the impact of Gal-3 and serum markers of cardiac ECM turnover on prognostic prediction of chronic systolic HF patients. Methods: Serum Gal-3, brain natriuretic peptide (BNP), extracellular matrix including type I and III aminoterminal propeptide of procollagen (PINP and PIIINP), matrix metalloproteinase-2, 9 (MMP-2, 9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) were analyzed. Cox regression analysis was used for survival analysis.

Results: A total of 105 (81 male) patients were enrolled. During 980±346 days follow-up, 17 patients died and 36 episodes of HF admission happened. Mortality of these patients was significantly associated with the log PIIINP (β= 15.380; P=0.042), log TIMP-1(β= 44.530; P=0.003), log MMP-2 (β= 554.336; P<0.001), log BNP (β= 28.273; P=0.034). Log Gal-3 (β= 7.484; P=0.066) is borderline associated with mortality. Mortality or first HF admission of these patients was significantly associated with the log TIMP-1(β= 16.496; P=0.006), log MMP-2 (β= 221.864; P<0.001), log BNP (β= 5.999; P=0.034). Log Gal-3 (β= 4.486; P=0.095) only showed borderline significance. In several models adjusting clinical parameters, log MMP-2 was significantly associated with clinical outcome. In contrast, log Gal-3 was not.

Conclusion: The prognostic strength of MMP-2 to clinical outcome prediction in HF patients is stronger than Gal-3.

Keywords: Gal-3, heart failure, MMP-2

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How to cite this article:
Chang YY, Chen A, Wu XM, Hsu TP, Liu LYD, Chen YH, Wu YW, Lin HJ, Hsu RB, Lee CM, Wang SS, Lo MT, Chen MF, Lin YH. Comparison the Prognostic Value of Galectin-3 and Serum Markers of Cardiac Extracellular Matrix Turnover in Patients with Chronic Systolic Heart Failure. Int J Med Sci 2014; 11(11):1098-1106. doi:10.7150/ijms.8083. Available from http://www.medsci.org/v11p1098.htm