International Journal of Medical Sciences

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23 October 2017

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Int J Med Sci 2014; 11(7):721-725. doi:10.7150/ijms.8718

Research Paper

Risk Factors for Long-term Outcome of Drug-eluting Stenting in Adults with Early-onset Coronary Artery Disease

Guipeng An1,2, Zhongqi Du1,2, Xiao Meng1,2, Tao Guo1,2, Guishuang Li1,2, Yuguo Chen1,2, Jifu Li1,2, Fengshuang An1,2, Yun Zhang1,2, Wenjing Li3✉, Cheng Zhang1,2✉

1. The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong 250012, China;
2. Department of cardiology, Shandong University Qilu Hospital, Jinan, Shandong 250012, China;
3. Fine Arts School of Shandong University, Jinan, Shandong 250012, China.

Abstract

Objective We lack data on the long-term outcome of drug-eluting stenting in patients with early-onset coronary artery disease (CAD). Here, we investigated the association of traditional risk factors and major adverse cardiovascular events (MACEs) after drug-eluting stenting in patients with CAD who were < 50 years old. Methods We enrolled 437 consecutive CAD patients < 50 years old who underwent drug-eluting stenting and 132 subjects who were age- and sex-matched and angiographically shown to be disease free as controls. MACEs were analyzed in CAD patients for a median of 24 months [interquartile range 14-34 months]. Results Male patients accounted for 90.4% of cases. As compared with controls, patients with early-onset CAD had higher body mass index and rates of smoking, family history of CAD, and diabetes and hypercholesterolemia. During the hospital stay, 1 patient died, and the incidence of MACEs was 1.1%. At the end of follow-up, the overall death rate was 0.7%. MACEs were observed in 54 patients (12.4%). On Cox proportional hazard analyses, positive family history and diabetes were independent risk factors of MACEs (HR 2.61, 95% confidence interval 1.29-4.00, p = 0.002; and HR 2.48, 95% confidence interval 0.86-3.14, p = 0.004, respectively). Conclusions Drug-eluting stenting is a reliable treatment for patients with early-onset CAD. Positive family history of CAD and diabetes are independent risk factors of adverse cardiovascular events in this subgroup of patients after drug-eluting stent implantation.

Keywords: early onset coronary artery disease, drug-eluting stent, family history, diabetes, risk factor.

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How to cite this article:
An G, Du Z, Meng X, Guo T, Li G, Chen Y, Li J, An F, Zhang Y, Li W, Zhang C. Risk Factors for Long-term Outcome of Drug-eluting Stenting in Adults with Early-onset Coronary Artery Disease. Int J Med Sci 2014; 11(7):721-725. doi:10.7150/ijms.8718. Available from http://www.medsci.org/v11p0721.htm