International Journal of Medical Sciences

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22 October 2017

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Int J Med Sci 2014; 11(4):344-348. doi:10.7150/ijms.8140

Short Research Communication

Glial Scar Formation Occurs in the Human Brain after Ischemic Stroke

Lijie Huang1,2#, Zhe-Bao Wu1,2#, Qichuan ZhuGe1,2✉, WeiMing Zheng1,2, Bei Shao2, Brian Wang3, Fen Sun3, Kunlin Jin1,2,3✉

1. Department of Neurosurgery, First Affiliated Hospital, Wenzhou Medical University, Wenzhou 325000, China
2. Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, First Affiliated Hospital, Wenzhou Medical University, Wenzhou 325000, China
3. Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, Texas 76107, USA
# These authors made equal contributions to this paper

Abstract

Reactive gliosis and glial scar formation have been evidenced in the animal model of ischemic stroke, but not in human ischemic brain. Here, we have found that GFAP, ED1 and chondroitin sulphate proteoglycans (CSPG) expression were significantly increased in the cortical peri-infarct regions after ischemic stroke, compared with adjacent normal tissues and control subjects. Double immunolabeling showed that GFAP-positive reactive astrocytes in the peri-infarct region expressed CSPG, but showed no overlap with ED1-positive activated microglia. Our findings suggest that reactive gliosis and glial scar formation as seen in animal models of stroke are reflective of what occurs in the human brain after an ischemic injury.

Keywords: glial scar, reactive gliosis, ischemic stroke, human, patients

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How to cite this article:
Huang L, Wu ZB, ZhuGe Q, Zheng W, Shao B, Wang B, Sun F, Jin K. Glial Scar Formation Occurs in the Human Brain after Ischemic Stroke. Int J Med Sci 2014; 11(4):344-348. doi:10.7150/ijms.8140. Available from http://www.medsci.org/v11p0344.htm