23 January 2019
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Int J Med Sci 2014; 11(4):344-348. doi:10.7150/ijms.8140
Short Research Communication
Glial Scar Formation Occurs in the Human Brain after Ischemic Stroke
1. Department of Neurosurgery, First Affiliated Hospital, Wenzhou Medical University, Wenzhou 325000, China
Reactive gliosis and glial scar formation have been evidenced in the animal model of ischemic stroke, but not in human ischemic brain. Here, we have found that GFAP, ED1 and chondroitin sulphate proteoglycans (CSPG) expression were significantly increased in the cortical peri-infarct regions after ischemic stroke, compared with adjacent normal tissues and control subjects. Double immunolabeling showed that GFAP-positive reactive astrocytes in the peri-infarct region expressed CSPG, but showed no overlap with ED1-positive activated microglia. Our findings suggest that reactive gliosis and glial scar formation as seen in animal models of stroke are reflective of what occurs in the human brain after an ischemic injury.
Keywords: glial scar, reactive gliosis, ischemic stroke, human, patients
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How to cite this article:
Huang L, Wu ZB, ZhuGe Q, Zheng W, Shao B, Wang B, Sun F, Jin K. Glial Scar Formation Occurs in the Human Brain after Ischemic Stroke. Int J Med Sci 2014; 11(4):344-348. doi:10.7150/ijms.8140. Available from http://www.medsci.org/v11p0344.htm