International Journal of Medical Sciences

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23 October 2017

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Int J Med Sci 2014; 11(2):209-214. doi:10.7150/ijms.6801

Review

Masticatory Deficiency as a Risk Factor for Cognitive Dysfunction

Francisco Bruno Teixeira1, Luanna de Melo Pereira Fernandes1,2, Patrycy Assis Tavares Noronha3, Marcio Antonio Raiol dos Santos1, Walace Gomes-Leal3, Cristiane do Socorro Ferraz Maia2, Rafael Rodrigues Lima1 ✉

1. Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, 66075-900, Belém-Pará, Brazil;
2. Laboratory Pharmacology of Inflammation and Behavior, Institute of Health Sciences, Federal University of Pará, 66075-900, Belém-Pará, Brazil;
3. Laboratory of Experimental Neuroprotection and Neuroregeneration, Institute of Biological Sciences, Federal University of Pará, 66075-900, Belém-Pará, Brazil.

Abstract

Several studies have demonstrated that chewing helps to maintain cognitive functions in brain regions including the hippocampus, a central nervous system (CNS) region vital for memory and learning. Epidemiological studies suggest that masticatory deficiency is associated with development of dementia, which is related to spatial memory deficits especially in older animals. The purpose of this paper is to review recent work on the effects of masticatory impairment on cognitive functions both in experimental animals and humans. We show that several mechanisms may be involved in the cognitive deficits associated with masticatory deficiency. The epidemiological data suggest a positive correlation between masticatory deficit and Alzheimer's disease. It may be concluded that chewing has important implications for the mechanisms underlying certain cognitive abilities.

Keywords: Chewing, Cognition, Learning, Memory, Masticatory, Hippocampus.

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How to cite this article:
Teixeira FB, de Melo Pereira Fernandes L, Noronha PAT, dos Santos MAR, Gomes-Leal W, do Socorro Ferraz Maia C, Lima RR. Masticatory Deficiency as a Risk Factor for Cognitive Dysfunction. Int J Med Sci 2014; 11(2):209-214. doi:10.7150/ijms.6801. Available from http://www.medsci.org/v11p0209.htm