19 October 2017
Int J Med Sci 2014; 11(1):34-43. doi:10.7150/ijms.7548
A Comparative Clinical Study on Five Types of Compression Therapy in Patients with Venous Leg Ulcers
1. Department of Medical Biophysics, Medical University of Silesia in Katowice, Poland
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How to cite this article:
Dolibog P, Franek A, Taradaj J, Dolibog P, Blaszczak E, Polak A, Brzezinska-Wcislo L, Hrycek A, Urbanek T, Ziaja J, Kolanko M. A Comparative Clinical Study on Five Types of Compression Therapy in Patients with Venous Leg Ulcers. Int J Med Sci 2014; 11(1):34-43. doi:10.7150/ijms.7548. Available from http://www.medsci.org/v11p0034.htm
The aim of this study was to compare five types of compression therapy in venous leg ulcers (intermittent pneumatic vs. stockings vs. multi layer vs. two layer short stretch bandages vs. Unna boots). Primary study endpoints were analysis of changes of the total ulcer surface area, volume and linear dimensions inside observed groups. The secondary end points were comparisons between all groups the number of completely healed wounds (ulcer healing rates), Gilman index and percentage change of ulcer surface area. In total, 147 patients with unilateral venous leg ulcers were included to this study. Participants were randomly allocated to the groups: A, B, C, D and E. After two months the healing rate was the highest in group A (intermittent pneumatic compression) - 57.14%, 16/28 patients, B (ulcer stocking system) - 56.66%, 17/30 patients and C (multi layer short stretch bandage) - 58.62%, 17/29 patients. Significantly much worse rate found in group D (two layer short stretch bandages) - only 16.66%, 5/30 patients and E (Unna boots) - 20%, 6/30 patients. The analysis of changes of the percentage of Gilman index and wound total surface area confirmed that intermittent pneumatic compression, stockings and multi layer bandages are the most efficient. The two layer short - stretch bandages and Unna boots appeared again much less effective.
Keywords: compression stockings, short stretch bandages, Unna boots, venous leg ulcers, wound healing
Venous leg ulcers pose a serious clinical dilemma and an economic burden on health services. About 1%-2% of the whole population and 3%-5% of the population over 65 years of age will suffer from a leg ulcer during their lifetime [1, 2]. However, in a typical Western population where the average age is steadily increasing, the burden placed upon the health economy by venous ulceration looks set to increase proportionally. Cost effective treatment of venous disorders is therefore vital.
Venous ulcers alone have been estimated to cost the National Health Service £400 million a year in the United Kingdom . Studies in Germany  calculated the mean total cost of a VLU per patient per year to be €9569 (€8658 - 92% direct costs). According to Collins and Seraj  the financial burden of venous ulcers is estimated to be $2 billion per year in the United States.
The occurrence and the treatment of chronic leg ulcer generate significant costs related to the necessity of often expensive and long-term therapy. In the United States alone, between 500000 and 1000000 people suffer from chronic leg ulcers, the majority of which result from venous insufficiency. An improvement in the knowledge concerning venous ulcer pathophysiology as well as an implementation of modern therapy such tissue debridement, colloid dressings, apligraf application (Tissue, Infection, Moisture and Edge framework - TIME strategy - in chronic wound treatment) significantly improved the rate of the healed ulcers. However, despite this progress, the number of patients with resistive or recurrent venous ulcer still remains relatively high. Some European studies [1, 4] have reported that recurrence rate of venous ulcers is 20% to 23% in 5 year follow up, which has a considerable impact on health and quality of life in terms of patient pain and social isolation. This fact stimulates new findings as well as an implementation of new methods and medicines in this field [6, 7].
Clinical studies [8-20] have examined the efficient effects (healing outcomes) of compression therapy on leg ulcers. But in the literature, there are many methods of applying external graduated compression, such as elasticised bandages, Unna's boots, multilayer elastic compression bandages, short stretch bandages and elastomeric hosiery. The differences in effectiveness of various types of compression are not clear. The authors are still not sure as to which compression techniques, and pressure values are clinically the best (Table 1), easy to use and not expensive.
The aim of our study was to compare five types of compression therapy in venous leg ulcers (intermittent pneumatic vs. stockings vs. multi layer vs. two layer short stretch bandages vs. Unna boots). Primary study endpoints were analysis of changes of the total ulcer surface area, volume and linear dimensions inside observed groups. The secondary end points were comparisons between all groups the number of completely healed wounds (ulcer healing rates), Gilman index and percentage change of ulcer surface area.
Materials and methods
All participants provided informed consent to this project that was approved by the local Bioethics Committee of the Medical University of Silesia in Katowice (protocol number NN/6501/101/06). The subjects signed written agreement forms. The trial is registered in Australian and New Zealand Clinical Trials Registry (ACTRN12613001213730).
Compression therapy and literature
**percentage decrease of wound area
Settings and Participants
A prospective, randomized, comparative study was conducted from June 2010 to January 2013 in Silesia, Poland. Patients with the venous leg ulcers were included in the study. The exclusion criteria were: (1) an ankle brachial pressure index (ABPI) lower than 1.0, (2) diabetes, (3) cancer, (4) peripheral nerve injury, (5) rheumatoid arthritis, (6) ventricular arrhythmia, (7) cardiac pacemaker, (8) ulcer surgery, (9) skin infection, (10) pregnancy and (11) after steroid therapy, (12) bilateral ulcers. The (13) lymphedema, (14) pulmonary edema and (15) congestive heart failure, (16) chronic renal failure were exclusion criteria in our protocol too (Figure 1).
In total, 117 patients with unilateral venous leg ulcers were included to this study. Participants were randomly allocated to four groups A, B, C, D and E.
All ulcers in these groups were diagnosed as venous. Patients were examined (9 segments - upper and lower greater saphenous vein, short saphenous vein, proximal and distal femoral vein, proximal and distal popliteal vein, saphenofemoral junction and saphenopopliteal junction) by duplex scanning (EUB 555, Hitachi Inc, Japan). The thigh veins were examined with the participant standing, whereas the calf veins were examined in the sitting position, with the leg dependent. Each vein segment was imaged both in crosssection and longitudinally. When the vessels were imaged in cross -section, the direction of the Doppler shift was represented by a color scale over the blood vessels (red = flow in proximal direction, blue = flow in distal, retrograde direction). In longitudinal images, the numerical velocity of red blood cells within each segment was plotted against time. A transient increase in proximal flux was generated by manually squeezing the limb distal to the segment under examination. On releasing the distal compression, significant amounts of blood pass distally (pathological reflux) if the valve proximal to the site of examination does not close properly. For assessment of the calf veins, the foot was compressed; for assessment of the thigh veins, the calf was compressed. Criteria for pathological reflux were duration 0.5 s and peak reflux velocity 10 cm/s. The Doppler examination was provided on both legs.
All patients had the symptoms of chronic venous insufficiency (CVI), i.e. edema, skin hyperpigmentation and lipo-dermatosclerosis of the affected limb. The body mass index (BMI) was calculated for all patients. According to international norms, a BMI higher than 30 kg/m2 indicated adipositas. The number of smokers was recorded as well. According to inclusion/exclusion criteria protocol the recruited participants before experiment had complex tests measured twice within the past three months (standard blood morphology, immunological studies, HbA1c, cholesterol panel and liver enzymes, serum creatinine/glomerular filtration rate, urine testing, ECG).
Randomization and Intervention
Computer-generated random numbers were sealed in sequentially numbered envelopes and group allocation was independent of time and persons delivering the treatment. The physician allocating patients to groups had 147 envelopes, each containing a piece of paper marked with A, B, C, D and E groups. The physician would draw and open an envelope in the presence of a physiotherapist to see the symbol and direct the patient to one of the comparative groups accordingly. The patients were treated in Department of Dermatology of Medical University of Silesia.
The study design, methodology, and treatment were programmed by coordinators (physiotherapist, general and vascular surgeons, and an internist from Department of Physiotherapy Basics of Academy of Physical Education, Department of Internal Medicine, and Department of Vascular Surgery of Medical University of Silesia). Standard care, planimetry measurements, and data collection were provided by a nurse from Department of Dermatology of Medical University of Silesia. The compression therapy was performed by a physiotherapist from Department of Dermatology of Medical University of Silesia. The final statistical analysis was performed by a technician form Department of Medical Biophysics of Medical University of Silesia. A nurse from hospital collected data and coded them to the Excel database. The “blinded” results were transferred to Statistica version 10.0 database by a technician from Department of Medical Biophysics. The research coordinators had no contact with patients and could not identify them.
All participating facilities provided patients a standard regimen of drug therapy (standard regimen was carried out for 2 months to begin our experiment - application one of five compression procedures in following group), including micronized purified flavonoid fraction 450 mg diosmin, 50 mg hesperidin, 2 tablets of 500 mg (Daflon 500) once daily.
Patients in group A received 12 - chamber intermittent pneumatic compression therapy. The Flowtron Hydroven 12 System device (Huntleigh Healthcare, UK) was applied to compress the cuff covers the foot, lower leg, knee and thigh. Cuff length was 109 cm (a foot for 33 cm). Cuff expanded from foot (circumference 38 cm) to thigh (circumference 71 cm). All patients were subjected to a pressure of 60 mmHg at the ankle. In the upper chamber pressure was exerted smaller and decreases with the height (40 mmHg in the chamber at the level of the groin. Ventricular filling time was 60 s, and a discharge time of 30 s. A single setting lasted 60 min during treatment, patients were lying. The pneumatic compressions were provided once daily, 5 times a week for 2 months.
Patients in group B were treated with special ulcer stocking system Ulcer X (Sigvaris, Gianzoni & Cie AG, Switzerland) providing pressure 30 - 40 mmHg at the ankle. The system were put on the leg at the outpatient clinic every morning and worn whole day (about 10-12 hours); and put off on night.
Patients in group C were treated with multi layer short-stretch bandaging (Sigvaris, Gianzoni & Cie AG, Switzerland). The pressure values were also standardized in use of Kikuhime (Advancis Medical, UK) manometer (45-50 mmHg for superficial reflux and 50-55 mmHg for superficial with deep venous reflux). Bandages were applied in four layers with spinal turns on foot and turns in eight on calf. The bandages were worn day (10 - 12 hours) and put off on night.
Patients in group D were treated with two layer short-stretch bandaging (Sigvaris, Gianzoni & Cie AG, Switzerland). The pressure values were also standardized in use of Kikuhime manometer (20-25 mmHg for superficial reflux and 25-30 mmHg for superficial with deep venous reflux). Treatment was with the same methodology as in group C.
Patients from group E underwent the compression treatment by means of Unna's boot. After rinsing the wound with physiological sodium chloride solution, Unna's rigid paste bandage was tied around the limbs from below the toes up to the knee. This dressing was changed every 7 days.
In all groups therapy lasted two months. The compressions were applied by a clinic physiotherapist, who was a professional practitioner (with 15 years of experience). The therapist completed a course on management of leg ulcers and additional training before experiment (20 days to practice applying bandaging with Kikuhime manometer).
Outcomes and measurements
The therapy progress was assessed using analysis of healing rates and digital planimetry - total ulcer surface area (cm2), length and width (cm), volume (cm3) - in use of digitizer (Kurta XGT, Altek Inc, USA). Ulcers were photographed and size was recorded weekly by transferring their homothetic, congruent images onto transparent film sheets. The contours showed wound perimeters and granulation tissue areas and were also used to measure wound longest lengths and longest (perpendicular) widths with a centimeter ruler. Wound depth was measured using a digital caliper with a depth gauge (MIB-Messzeuge IP67 Germany) at the site where the wound was the deepest. The tip of the gauge had a soft, disposable, sterile cap that prevented the bed of the wound from being damaged. The site where depth was measured was also marked on the contour. The images then were measured with a planimeter. The electronic equipment measuring pressure ulcer area and volume consisted of a digitizer wired to a personal computer with upgraded software (C-GEO v. 4.0 Nadowski, Poland) for calculating and storing pressure ulcer area, perimeter, and volume measurements.
The healing process between groups were assessed using:
d - Gilman Index (cm)
SI - initial total area (cm2)
SF - final wound total area after two months (cm2)
CI - initial circumference (cm)
CF - final wound circumference after two months (cm)
ΔS% - percentage change of the total surface area (%)
SI - initial total area (cm2)
SF - final wound total area after two months (cm2)
The x2 independence test and non-parametric Kruskal-Wallis two - way analysis, which is an element of a module of the analysis of variance, were used for comparing indicators, which characterized patients in all comparative groups. Outcome measurements were compared between the groups by using Fisher test, Kruskal-Wallis analysis of variance (post hoc Tukey's test) and inside the groups non-parametric Wilcoxon signed - rank test. Two sided “P” (level of significance) values of less than 0.05 were considered to be statistically significant.
The participant characteristics assessed before randomization are shown in Table 2 and 3. Patients were evaluated using the clinical, etiological, anatomical and pathological elements (CEAP) classification of chronic venous insufficiency (Table 4) and were homogenous.
Treatment in all comparative groups appeared efficient (Table 5). However, after completion of the study, it was found that the healing rate (number of completely healed ulcer) was the highest in group A (intermittent pneumatic compression) - 57.14%, 16/28 patients, B (ulcer stocking system) - 56.66%, 17/30 patients and C (multi layer short stretch bandage) - 58.62%, 17/29 patients (“P” values and more in Figure 2). Significantly much worse rate found in group D (two layer short stretch bandages) - only 16.66%, 5/30 patients and E (Unna boots) - 20%, 6/30 patients (see Figure 2).
The analysis of changes of the percentage of Gilman index and wound total surface area confirmed that intermittent pneumatic compression, stockings and multi layer bandages are the most efficient. The two layer short - stretch bandages and Unna boots appeared again much less effective (other details in Figure 3 and 4).
Characteristics of participants and ulcers
*the χ2 test
**the Kruskal - Wallis analysis
Other clinical findings of participants in the trial
*the χ2 test
The CEAP in patients with venous leg ulcers
*the χ2 test
C6EPAS2,3PR (open ulcer, primary etiology, venous reflux in upper and lower segments of greater saphenous vein)
C6EPAS4PR (open ulcer, primary etiology, venous reflux in short saphenous vein)
C6EPAS2,D13PR (open ulcer, primary etiology, venous reflux in upper segments of greater saphenous and femoral vein)
C6EPAS3,D13PR (open ulcer, primary etiology, venous reflux in lower segments of greater saphenous and femoral vein)
C6EPAS2,3D13PR (open ulcer, primary etiology, venous reflux in upper/lower segments of greater saphenous and femoral vein
C6EPAS2,3D13,14,P18PR (open ulcer, primary etiology, venous reflux in upper/lower segments of greater saphenous, popliteal and femoral veins, saphenofemoral and saphenopopliteal junctions)
Results in patients with venous leg ulcers
Comparison between groups in terms of healing rate. *Fisher test. Legends: - groups A and D (57.14% vs. 16.66%, P=0.03), - groups B and D (56.66% vs.16.66%, P=0.03), - groups C and D (58.62% vs. 16.66%, P=0.03), - groups A and E (57.14% vs. 20.00%, P=0.03), - groups B and E (56.66% vs.20.00%, P=0.03), - groups C and E (58.62% vs. 20.00%, P=0.03).(Click on the image to enlarge.)
Comparison between groups in terms of Gilman index [cm]. * the Kruskal-Wallis analysis. Legends: - groups A and D (0.52 cm vs. 0.20 cm, P=0.04), - groups B and D (0.49 cm vs. 0.20 cm, P=0.04), - groups C and D (0.51 cm vs. 0.20 cm, P=0.04), - groups A and E (0.52 cm vs. 0.23 cm, P=0.04), - groups B and E (0.49 cm vs. 0.23 cm, P=0.04), - groups C and E (0.51 cm vs. 0.23 cm, P=0.04).(Click on the image to enlarge.)
Comparison between groups in terms of change of the percentage ulcer size. * the Kruskal-Wallis analysis. Legends: - groups A and D (48.11% vs. 17.77%, P=0.04), - groups B and D (41.22% vs. 17.77%, P=0.04), - groups C and D (49.02% vs. 17.77%, P=0.04), - groups A and E (48.11% vs. 20.48%, P=0.04), - groups B and E (41.22% vs. 20.48%, P=0.04), - groups C and E (49.02% vs. 20.48%, P=0.04).(Click on the image to enlarge.)
In our trial the most effective therapeutic procedure for the treatment of venous leg ulcers is the use of intermittent pneumatic compression, stockings and multi layer compression bandaging (on similar level). However in this study, two - layer compression therapy with bandages proved to be the least effective.
Researchers have not analyzed so far such various forms of compression therapy in one prospective, randomized, controlled, clinical trial. This study is the first attempt of comparing such many compression methods and we are able only to relate our results to incomplete data in the literature.
There is only one reliable meta - analysis (Cochrane Review) connected with intermittent pneumatic compression in venous leg ulcers. Nelson et al.  in 2011 year included trials that compared the effects of pneumatic compression with control (sham or no compression) or made comparisons between intermittent compression treatment regimens, in VLU management. The authors identified only seven randomized controlled trials (including 367 patients in total). Only one trial was at low risk of bias having reported adequate randomization, allocation concealment and blinded outcome assessment. In one trial (80 people) more ulcers healed with intermittent compression than with dressings (62% vs. 28%, P=0.002). Four trials compared intermittent pneumatic plus compression with compression alone. The first of these trials (45 patients) found increased ulcer healing with intermittent pneumatic plus compression than with compression alone (risk ratio for healing 11.4, 95% confidence interval 1.6 to 82). The remaining three trials (122 patients) found no evidence of a benefit for intermittent pneumatic plus compression compared with compression alone. One small trial (16 patients) found no difference between intermittent compression therapy (without additional compression) and compression bandages alone. One trial compared different ways of delivering intermittent compression and found that rapid pneumatic procedures healed more ulcers than slow procedures (86% vs. 61%).
In our study we did not provide a professional observation of participant satisfaction, but on the basis of verbal communication of our patients the intermittent pneumatic compression appeared comfortable too. We did not notice any undesirable effects.
Vowden  maintains that even with the application of four - layer bandaging the recommended treatment for leg ulcers, patients with reduced mobility have delayed ulcer healing. An extensive review of the literature (in following article) has demonstrated that the use of this treatment on patients with reduced mobility has not been previously studied; yet, analysis of difficult - to - heal ulcer patients would indicate that this method of treatment may be appropriate and requires further study.
In our study stockings (healing rate after two months therapy 56.66%) appeared such effective as multi layer bandaging (58.62%) and much more efficient than only two - layer compression therapy (16.66%) and Unna boots (only 20%). In literature are only a few meta - reports connected with those issues.
O'Meara et al.  in their meta - analysis compared effectiveness of two types of compression treatment (four layer bandage and short stretch bandage) in people with venous leg ulceration. Seven eligible trials were identified (887 patients), and patient level data were retrieved for five (797 patients, 90% of known randomized patients). The four layer bandage was associated with significantly shorter time to healing: hazard ratio (95% confidence interval) from multifactorial model based on five trials was 1.31 (1.09 to 1.58), P=0.005. Larger ulcer area at baseline, more chronic ulceration, and previous ulceration were all independent predictors of delayed healing. Data from two trials showed no evidence of a difference in adverse event profiles between the two bandage types. In Cochrane Database from 2012  included forty-eight randomized clinical trials reporting (4321 participants in total). In conclusion authors stated that compression increases ulcer healing rates compared with no compression. Multi-component systems are more effective than single-component systems. Multi-component systems containing an elastic bandage appear to be more effective than those composed mainly of inelastic constituents. Two-component bandage systems appear to perform as well as the multi-layered compression. Patients receiving the multi-layered bandaging heal faster than those allocated the single layered. More patients heal on high-compression stocking systems. Further data are required before the difference between high-compression stockings and the multi-layered bandages can be established.
Cullum et al.  searched MEDLINE, CINAHL, EMBASE and the Cochrane Controlled Trials Register (CENTRAL) and stated that multi-layered high compression is more effective than single-layer compression. High-compression hosiery was more effective than moderate compression in preventing ulcer recurrence. The authors concluded that further studies are needed.
In United States and European countries, Unna boots (a noncompliant, plaster-type bandage) are often applied by practitioners in many venous ulcer patients, but unfortunately without randomized controlled clinical trials.
For example, American researchers  evaluated the utility of weekly Unna boot therapy in decreasing postoperative edema, inflammation, and morbidity; minimizing postoperative wound care; and improving the rate of wound healing in patients with lower leg surgical defects. In all 10 patients, weekly Unna boot therapy was well tolerated, with high satisfaction levels relating to minimal postoperative wound care, rapid granulation, minimal pain, and excellent esthetic outcome of postoperative wounds. No infections or other complications were noted during the healing process. In weakness of their work authors stated that this was not a randomized well controlled clinical study. In literature there are more controversies [6, 26].
Limitations of the study
To this moment we were unable to present long term results - longer observation than two months (and follow up of recurrence process after 1 and 2 years - to calculate Kaplan - Meier survival analysis with log rank comparisons). Although study outcomes were consistent in each treatment group, the absence of blinding and use of placebo are a limitation of this study that may affect the generalization of the findings. In future we would like to provide quasi - compression therapy in control groups and present complete results. We did not use intention-to-treat analysis either.
The results of our study show that intermittent pneumatic compression systems, stockings and multi layer bandaging are very useful and effective in venous leg ulcer treatment. The two - layer short stretch bandages and Unna boots are not efficient. Future clinical studies and meta-analyses are needed, especially connected with cost of effective therapies and bigger sample size and major omissions according to the CONSORT statement.
The authors would like to certify that have no commercial associations with the manufacturers of the equipment described in the manuscript and other conflict of interest.
1. Carpentier PH, Maricq HR, Biro C. et al. Prevalence, risk factors, and clinical patterns of chronic venous disorders of lower limbs: a population based study in France. J Vasc Surg. 2004;40:650-659
2. Jones RH, Carek PJ. Management of varicose veins. Am Fam Phys. 2008;78(11):1289-1294
3. Simon DA, Dix FP, McCollum C. Management of venous leg ulcers. BMJ. 2004;328:1358-1362
4. van Gent WB, Wilschut ED, Wittens C. Management of venous ulcer disease. BMJ. 2010;34:c6045
5. Collins L, Seraj S. Diagnosis and treatment of venous ulcers. Am Fam Phys. 2010;15:989-996
6. Kucharzewski M, Kozka M Urbanek T. Topical Treatment of Nonhealing Venous Leg Ulcer with Propolis Ointment. Evid Based Complement Alternat Med. 2013:ID254017
7. Waniczek D, Kozowicz A, Muc - Wierzgon M. et al. Adjunct Methods of the Standard Diabetic Foot Ulceration Therapy. Evid Based Complement Alternat Med. 2013:ID243568
8. O'Donnell TF, Balk EF. The need for an Intersociety Consensus Guideline for venous ulcer. J Vasc Surg. 2011;54:83-90
9. Duby T, Cherry G, Hoffman D. et al. A randomized trial in the treatment of venous leg ulcers comparing short stretch bandages, four layer bandage system, and a long stretch - paste bandage system. Wounds. 1993;5:276- 269
10. Colgan MP, Teevan M, McBride M. et al. Cost comparisons in the management of venous ulceration. 5th European Conference on Advances in Wound Management. 1993 103
11. Danielsson G, Arfvidsson B, Eklof B, Kistner RL. Reflux from thigh to calf, the major pathology in chronic venous ulcer disease: surgery indicated in the majority of patients. Vasc Endovasc Surg. 2004;38:209- 219
12. Vowden K. The use of intermittent pneumatic compression in venous ulceration. Br J Nurs. 2001;10:491-509
13. Partsch H, Damstra RJ, Tazelaar DJ. et al. Multicentre, randomized controlled trial of four - layer bandaging versus short - stretch bandaging in the treatment of venous leg ulcers. VASA. 2001;30:108- 113
14. Meyer FJ, Burnand KG, Lagattola NR, Eastham D. Randomized clinical trial comparing the efficacy of two bandaging regimens in the treatment of venous leg ulcers. Br J Surg. 2002;89:810
15. O'Brien JF, Grace PA, Perry IJ at al. Randomized clinical trial and economic analysis of four - layer compression bandaging for venous ulcers. Br J Surg. 2003;90:1307
16. Franks PJ, Moody M, Moffat CJ at al. Randomized trial of cohesive short - stretch versus four - layer bandaging in the management of venous ulceration. Wound Rep Regen. 2004;12:157- 160
17. Junger M, Wollina U, Kohnen R, Rabe E. Efficacy and tolability of an ulcer compression stocking for therapy of chronic venous ulcer compared with a beelow - knee compression bandage: results from a prospective, randomized, multicentre trial. Curr Med Res Opin. 2004;20:1613- 1623
18. Vanscheidt W, Kohnen R, Achhammer I. Tubulcus - Kompressionstherapie des venosen ulcus cruris. Phlebologie. 2004;33:12- 16
19. Brizzio EO, Blatter W, Rossi G. et al. Healing venous ulcers with different modalities of leg compression: unexpected findings of a pilot study, Phlebologie. 2006;35:349-355
20. O'Meara S, Tierney J, Cullum N. et al. Four layer bandage compared with short stretch bandage for venous leg ulcers: review and meta-analysis of randomized controlled trials with data from individual patients. BMJ. 2009;338:1344-1353
21. Gilman TH. Parameter for measurement of wound closure. Wounds. 1990;3:95-101
22. Nelson EA, Mani R, Thomas K. et al. Intermittent pneumatic compression for treating venous leg ulcers. Cochrane Database Syst Rev. 2011;16:CD001899
23. O'Meara S, Cullum N, Nelson EA, Dumville JC. Compression for venous leg ulcers. Cochrane Database Syst Rev. 2012;14:CD000265
24. Cullum N, Nelson EA, Flemming K, Sheldon T. Systematic reviews of wound care management: beds; compression; laser therapy, therapeutic ultrasound, electrotherapy and electromagnetic therapy. Health Technol Assess. 2001;5:1-221
25. Stebbins WG, Hanke CW, Petersen J. Enhanced healing of surgical wounds of the lowerleg using weekly zinc oxide compression dressings. J Dermatol Surg. 2011;37:158-165
26. Schaum KD. Unna boots versus multilayered, sustained, graduated high compression bandage systems. Ostomy Wound Manage. 2005;51:30
Corresponding author: Prof. Jakub Taradaj, Department of Physiotherapy Basics, Academy of Physical Education in Katowice, Mikolowska Street 72, building B 40-065, Poland. j.taradajkatowice.pl