23 October 2017
Int J Med Sci 2013; 10(11):1575-1577. doi:10.7150/ijms.6436
Short Research Communication
Metabolome Analysis of Erythrocytes from Patients with Chronic Hepatitis C Reveals the Etiology of Ribavirin-Induced Hemolysis
1. Department of Gastroenterology, Yamagata University School of Medicine, Yamagata, Yamagata 990-9585;
Ribavirin is one of the major agents used in combination therapy with interferon for chronic hepatitis C, but is often associated with hemolytic anemia as a serious adverse event. Employing metabolome analysis, we demonstrated that the concentrations of intermediate metabolites produced by glycolysis and the pentose phosphate cycle in patients' erythrocytes were significantly decreased after administration of ribavirin. Our findings suggest that hemolysis associated with ribavirin is triggered by an energy crisis and consequent oxidative stress, thus having implications for the prevention of such hemolysis.
Keywords: HCV, ribavirin, anemia, metabolome, glycolysis, pentose phosphate cycle.
This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Karasawa T, Saito T, Ueno Y, Sugimoto M, Soga T. Metabolome Analysis of Erythrocytes from Patients with Chronic Hepatitis C Reveals the Etiology of Ribavirin-Induced Hemolysis. Int J Med Sci 2013; 10(11):1575-1577. doi:10.7150/ijms.6436. Available from http://www.medsci.org/v10p1575.htm