International Journal of Medical Sciences

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20 October 2017

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Int J Med Sci 2013; 10(7):857-863. doi:10.7150/ijms.5870

Research Paper

Thyroid-Stimulating Hormone Is Significantly Associated with Bone Health Status in Men

Kok-Yong Chin1, Soelaiman Ima-Nirwana1✉, Isa Naina Mohamed1, Amilia Aminuddin2, Mohamad Hanapi Johari3, Wan Zurinah Wan Ngah3

1. Pharmacology Department, Faculty of Medicine, Universiti Kebangsaan Malaysia.
2. Physiology Department, Faculty of Medicine, Universiti Kebangsaan Malaysia.
3. Biochemistry Department, Faculty of Medicine, Universiti Kebangsaan Malaysia.

Abstract

Background and Aim: Recent studies revealed a novel association between thyroid-stimulating hormone (TSH) and bone health status in healthy male populations. The present study aimed to validate this association and provide new information on the relationship between TSH levels and calcaneal speed of sound (SOS) in men.

Methods: This cross-sectional study recruited 681 men with complete data of calcaneal SOS, body anthropometry, serum TSH, free triiodothyronine (FT3) and free thyroxine (FT4) levels.

Results: All subjects had FT3 and FT4 levels within the in-house reference range and 13 subjects had lower than normal TSH levels. The results revealed that the SOS value of subjects was significantly associated with TSH after multiple adjustments (p<0.05). When subjects were divided into quintiles according to their TSH levels, the difference of SOS between men with low-normal TSH and high-normal TSH contributed significantly to the association between TSH and bone health status (p<0.05). The significance of the association persisted with the inclusion and exclusion of subclinical hyperthyroid subjects.

Conclusions: There was a significant association between TSH levels and bone health status in men as assessed by quantitative ultrasound. This age-independent association between TSH and SOS might explain some of the individual variation of bone health status in men.

Keywords: Thyroid-stimulating hormone, bone, calcaneus, men.

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How to cite this article:
Chin KY, Ima-Nirwana S, Mohamed IN, Aminuddin A, Johari MH, Ngah WZW. Thyroid-Stimulating Hormone Is Significantly Associated with Bone Health Status in Men. Int J Med Sci 2013; 10(7):857-863. doi:10.7150/ijms.5870. Available from http://www.medsci.org/v10p0857.htm