International Journal of Medical Sciences

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23 October 2017

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Int J Med Sci 2013; 10(2):171-175. doi:10.7150/ijms.5312

Research Paper

Biodegradable Conduit Small Gap Tubulization for Peripheral Nerve Mutilation: A Substitute for Traditional Epineurial Neurorrhaphy

Peixun Zhang1✉, Na Han1, Tianbing Wang1, Feng Xue1, Yuhui Kou1, Yanhua Wang1, Xiaofeng Yin1, Laijin Lu2, Guanglei Tian3, Xu Gong2, Shanlin Chen3, Yu Dang1, Jianping Peng1, Baoguo Jiang1✉

1. Department of Trauma & Orthopedics, Peking University People's Hospital, Beijing, China
2. Department of Orthopedics, First Hospital of Jilin University, Changchun, China
3. Department of Orthopedics, Beijing Jishuitan Hospital, Beijing, China

Abstract

Nerve regeneration and re-innervation are usually difficult after peripheral nerve injury. Epineurium neurorrhaphy to recover the nerve continuity is the traditional choice of peripheral nerve mutilation without nerve defects, whereas the functional recovery remains quite unsatisfactory. Based on previous research in SD rats and Rhesus Monkeys, a multiple centers clinical trial about biodegradable conduit small gap tubulization for peripheral nerve mutilation to substitute traditional epineurial neurorrhaphy was carried out. Herein, the authors reviewed the literature that focused on peripheral nerve injury and possible clinical application, and confirmed the clinical possibilities of biodegradable conduit small gap tubulization to substitute traditional epineurial neurorrhaphy for peripheral nerve mutilation. The biodegradable conduit small gap tubulization to substitute traditional epineurial neurorrhaphy for peripheral nerve mutilation may be a revolutionary innovation in peripheral nerve injury and repair field.

Keywords: Biodegradable Conduit, Epineurial Neurorrhaphy, Peripheral Nerve Mutilation, Small Gap, Tubulization

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How to cite this article:
Zhang P, Han N, Wang T, Xue F, Kou Y, Wang Y, Yin X, Lu L, Tian G, Gong X, Chen S, Dang Y, Peng J, Jiang B. Biodegradable Conduit Small Gap Tubulization for Peripheral Nerve Mutilation: A Substitute for Traditional Epineurial Neurorrhaphy. Int J Med Sci 2013; 10(2):171-175. doi:10.7150/ijms.5312. Available from http://www.medsci.org/v10p0171.htm