16 November 2018
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Int J Med Sci 2013; 10(2):141-147. doi:10.7150/ijms.5125
Short Research Communication
Creatine Metabolism and Safety Profiles after Six-Week Oral Guanidinoacetic Acid Administration in Healthy Humans
1. Center for Health, Exercise and Sport Sciences, Belgrade, Serbia.
Objectives; Guanidinoacetic acid (GAA) is a natural precursor of creatine, yet the potential use of GAA as a nutritional additive for restoring creatine availability in humans has been limited by unclear efficacy and safety after exogenous GAA administration. The present study evaluated the effects of orally administered GAA on serum and urinary GAA, creatine and creatinine concentration, and on the occurrence of adverse events in healthy humans. Methods and Results; Twenty-four healthy volunteers were randomized in a double-blind design to receive either GAA (2.4 grams daily) or placebo (PLA) by oral administration for 6 weeks. Clinical trial registration:
Keywords: Creatine synthesis, Creatinine, Clinical markers.
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How to cite this article:
Ostojic SM, Niess B, Stojanovic M, Obrenovic M. Creatine Metabolism and Safety Profiles after Six-Week Oral Guanidinoacetic Acid Administration in Healthy Humans. Int J Med Sci 2013; 10(2):141-147. doi:10.7150/ijms.5125. Available from http://www.medsci.org/v10p0141.htm