Multiple-, But Not Single-, Dose of Parecoxib Reduces Shoulder Pain after Gynecologic Laparoscopy

Zhang, Hufei; Shu, Haihua; Yang, Lu; Cao, Minghui; Zhang, Jingjun; Liu, Kexuan; Xiao, Liangcan; Zhang, Xuyu

doi:10.7150/ijms.4916

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Int J Med Sci 2012; 9(9):757-765. doi:10.7150/ijms.4916 This issue Cite

Research Paper

Multiple-, But Not Single-, Dose of Parecoxib Reduces Shoulder Pain after Gynecologic Laparoscopy

Hufei Zhang¹, Haihua Shu¹, Lu Yang¹, Minghui Cao², Jingjun Zhang¹, Kexuan Liu¹, Liangcan Xiao¹, Xuyu Zhang^1✉

1. Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China;
2. Department of Gynecologic Laparoscopic Medical Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

Citation:

Zhang H, Shu H, Yang L, Cao M, Zhang J, Liu K, Xiao L, Zhang X. Multiple-, But Not Single-, Dose of Parecoxib Reduces Shoulder Pain after Gynecologic Laparoscopy. Int J Med Sci 2012; 9(9):757-765. doi:10.7150/ijms.4916. https://www.medsci.org/v09p0757.htm

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Abstract

Background: The aim of this study was to investigate effect of single- and multiple-dose of parecoxib on shoulder pain after gynecologic laparoscopy.

Methods: 126 patients requiring elective gynecologic laparoscopy were randomly allocated to three groups. Group M (multiple-dose): receiving parecoxib 40mg at 30min before the end of surgery, at 8 and 20hr after surgery, respectively; Group S (single-dose): receiving parecoxib 40mg at 30min before the end of surgery and normal saline at the corresponding time points; Group C (control): receiving normal saline at the same three time points. The shoulder pain was evaluated, both at rest and with motion, at postoperative 6, 24 and 48hr. The impact of shoulder pain on patients' recovery (activity, mood, walking and sleep) was also evaluated. Meanwhile, rescue analgesics and complications were recorded.

Results: The overall incidence of shoulder pain in group M (37.5%) was lower than that in group C (61.9%) (difference=-24.4%; 95% CI: 3.4~45.4%; P=0.023). Whereas, single-dose regimen (61.0%) showed no significant reduction (difference with control=-0.9%; 95% CI: -21.9~20.0%; P=0.931). Moreover, multiple-dose regimen reduced the maximal intensity of shoulder pain and the impact for activity and mood in comparison to the control. Multiple-dose of parecoxib decreased the consumption of rescue analgesics. The complications were similar among all groups and no severe complications were observed.

Conclusions: Multiple-, but not single-, dose of parecoxib may attenuate the incidence and intensity of shoulder pain and thereby improve patients' quality of recovery following gynecologic laparoscopy.

Keywords: laparoscopic surgery, Shoulder pain, postoperative pain, nonsteroidal anti-inflammatory drugs

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APA

Zhang, H., Shu, H., Yang, L., Cao, M., Zhang, J., Liu, K., Xiao, L., Zhang, X. (2012). Multiple-, But Not Single-, Dose of Parecoxib Reduces Shoulder Pain after Gynecologic Laparoscopy. International Journal of Medical Sciences, 9(9), 757-765. https://doi.org/10.7150/ijms.4916.

ACS

Zhang, H.; Shu, H.; Yang, L.; Cao, M.; Zhang, J.; Liu, K.; Xiao, L.; Zhang, X. Multiple-, But Not Single-, Dose of Parecoxib Reduces Shoulder Pain after Gynecologic Laparoscopy. Int. J. Med. Sci. 2012, 9 (9), 757-765. DOI: 10.7150/ijms.4916.

NLM

CSE

Zhang H, Shu H, Yang L, Cao M, Zhang J, Liu K, Xiao L, Zhang X. 2012. Multiple-, But Not Single-, Dose of Parecoxib Reduces Shoulder Pain after Gynecologic Laparoscopy. Int J Med Sci. 9(9):757-765.

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