Int J Med Sci 2012; 9(8):730-737. doi:10.7150/ijms.4752 This issue Cite

Research Paper

Age- and Gender Dependent Association between Components of Metabolic Syndrome and Subclinical Arterial Stiffness in a Chinese Population

Chunyan Weng1, Hong Yuan1,2, Xiaohong Tang1, Zhijun Huang1, Kan Yang1, Wei Chen1, Pingting Yang3, Zhiheng Chen3, Fangping Chen3 ✉

1. Department of Cardiology, the Third Xiangya Hospital, Central South University, Changsha 410013, China;
2. Center of Clinical Pharmacology, the Third Xiangya Hospital, Central South University, Changsha 410013, China;
3. Health Management Center, the Third Xiangya Hospital, Central South University, Changsha 410013, China.

Citation:
Weng C, Yuan H, Tang X, Huang Z, Yang K, Chen W, Yang P, Chen Z, Chen F. Age- and Gender Dependent Association between Components of Metabolic Syndrome and Subclinical Arterial Stiffness in a Chinese Population. Int J Med Sci 2012; 9(8):730-737. doi:10.7150/ijms.4752. https://www.medsci.org/v09p0730.htm
Other styles

File import instruction

Abstract

Background: The aim of this study was to estimate the relationship between arterial stiffness and components of metabolic syndrome (MetS) in different age- and gender groups.

Methods: A total of 12,900 Chinese adults aged 20-79 years were recruited and stratified on the basis of gender and age. All participants underwent the measurement of waist circumference, blood pressure (BP), brachial-ankle pulse wave velocity (baPWV; an indicator of arterial stiffness), and blood chemistry. Multiple linear regression analysis was performed to evaluate the relationship between baPWV and above variables, to determine the relative influence of each component of MetS on baPWV.

Results: The prevalence of metabolic disorders except for low high-density lipoprotein cholesterol (HDL-C) was much higher in men than in women. All participants with MetS or any component of MetS except for low HDL-C had higher baPWV. BP was positively correlated with baPWV in all groups, while HDL-C was not correlated with baPWV in any groups. In addition, fasting glucose was related to baPWV in middle-aged adults and the elderly. Waist circumference had a positive association with baPWV in middle-aged adults and young men, triglyceride levels showed a significant correlation with baPWV in middle-aged women and young men. Of the MetS components, elevated BP was the strongest predictor of baPWV.

Conclusion: The prevalence of metabolic disorders and the association between baPWV and metabolic variables are dependent on age and gender. Different components of MetS exert distinct impacts on the baPWV in different age- and gender groups, with BP being the strongest predictor. It is suggested that age and gender should be taken into accounted in the management of MetS aiming to reduce subsequent complications.

Keywords: Gender difference, Metabolic syndrome, Brachial-ankle pulse wave velocity, Subclinical arterial stiffness.


Citation styles

APA
Weng, C., Yuan, H., Tang, X., Huang, Z., Yang, K., Chen, W., Yang, P., Chen, Z., Chen, F. (2012). Age- and Gender Dependent Association between Components of Metabolic Syndrome and Subclinical Arterial Stiffness in a Chinese Population. International Journal of Medical Sciences, 9(8), 730-737. https://doi.org/10.7150/ijms.4752.

ACS
Weng, C.; Yuan, H.; Tang, X.; Huang, Z.; Yang, K.; Chen, W.; Yang, P.; Chen, Z.; Chen, F. Age- and Gender Dependent Association between Components of Metabolic Syndrome and Subclinical Arterial Stiffness in a Chinese Population. Int. J. Med. Sci. 2012, 9 (8), 730-737. DOI: 10.7150/ijms.4752.

NLM
Weng C, Yuan H, Tang X, Huang Z, Yang K, Chen W, Yang P, Chen Z, Chen F. Age- and Gender Dependent Association between Components of Metabolic Syndrome and Subclinical Arterial Stiffness in a Chinese Population. Int J Med Sci 2012; 9(8):730-737. doi:10.7150/ijms.4752. https://www.medsci.org/v09p0730.htm

CSE
Weng C, Yuan H, Tang X, Huang Z, Yang K, Chen W, Yang P, Chen Z, Chen F. 2012. Age- and Gender Dependent Association between Components of Metabolic Syndrome and Subclinical Arterial Stiffness in a Chinese Population. Int J Med Sci. 9(8):730-737.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
Popup Image