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Int J Med Sci 2012; 9(8):621-626. doi:10.7150/ijms.4768

Research Paper

Correlations between Oxidative DNA Damage, Oxidative Stress and Coenzyme Q10 in Patients with Coronary Artery Disease

Yüksel KAYA1, Ayşegül ÇEBİ2✉, Nihat SÖYLEMEZ1, Halit DEMİR3, Hamit Hakan ALP4, Ebubekir BAKAN4

1. Kafkas University, Faculty of Medicine Department of Cardiology, Kars, Turkey.
2. Giresun University Faculty of Health Sciences, Giresun, Turkey.
3. Yüzüncü Yıl University Faculty of Science Department of Biochemistry, Van, Turkey.
4. Atatürk University Faculty of Medicine Department of Biochemistry, Erzurum, Turkey.

Abstract

The correlation of coronary artery disease (CAD) with pro-oxidant/antioxidant balance and oxidative DNA damage was investigated.

Seventy-seven patients with CAD and 44 healthy individuals as control were included in this study. The comparative ratios of ubiquinol-10/ubiquinone-10, 8-hydroxy-2'-deoxyguanosine/deoxyguanosine and the level of MDA measured by HPLC and the activities of GPX and SOD by colorimetric approach in blood samples obtained from patients with CAD were unraveled.

8-OHdG/dG ratios, serum MDA level and GPX activity were found significantly elevated level in serum of CAD patients compared to control group. The SOD activity was observed in stable levels in CAD patients. Ubiquinol-10/ubiquinone-10 ratio was significantly lower in patients with CAD than the controls.

The positive correlation was observed between 8-OHdG/dG ratios in both MDA levels and GPX activity, while the significant negative correlation was seemed between the ratio of 8-OHdG/dG and ubiquinol-10/ ubiquinone-10 as well as MDA levels and ubiquinol-10/ ubiquinone-10 ratio.

We conclude that, both the disruption of pro-oxidant/antioxidant balance and oxidative stress in DNA may play an important role in the pathogenesis of coronary artery disease.

Keywords: CoenzymeQ10, 8-hydroxy-2'-deoxyguanosine, malondialdehyde, oxidative stress, antioxidants, coronary artery disease.

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How to cite this article:
KAYA Y, ÇEBİ A, SÖYLEMEZ N, DEMİR H, ALP HH, BAKAN E. Correlations between Oxidative DNA Damage, Oxidative Stress and Coenzyme Q10 in Patients with Coronary Artery Disease. Int J Med Sci 2012; 9(8):621-626. doi:10.7150/ijms.4768. Available from http://www.medsci.org/v09p0621.htm