International Journal of Medical Sciences

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15 December 2017

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Int J Med Sci 2012; 9(7):603-610. doi:10.7150/ijms.4970

Research Paper

Is Helicobacter Pylori Infection Associated with Asthma Risk? A Meta-Analysis Based on 770 Cases and 785 Controls

Yan Wang1✉, Yutian Bi1, Liang Zhang2, Changzheng Wang1 ✉

1. Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing, China
2. Department of Environmental Hygiene, College of Preventive Medicine, Third Military Medical University, Chongqing, China

Abstract

Objective: Helicobacter pylori (H. pylori) infection has been thought to play a critical role in disorders such as gastric and lung cancer. A number of studies have been devoted to the relationship between H. pylori infection and asthma risk, which have generated inconclusive results. In this study we aimed to derive a more precise estimation of the relationship.

Methods: Meta-analyses evaluating the association of H. pylori infection and asthma risk were conducted and subgroup analyses on ethnicity and source of controls as well as CagA status were further conducted. Eligible studies were identified for the period up to Jul 2012.

Results: A total of five case-control studies comprising 770 cases and 785 controls were lastly selected for analysis. The overall data failed to indicate a significant association of H. pylori infection and asthma risk (OR=1.01; 95%CI=0.82-1.24). Likewise, in the subgroup analysis regarding ethnicity, source of controls and CagA status, no associations could be observed.

Conclusions: The pooled data failed to suggest a marked association between H. pylori infection and asthma risk. Future studies are needed to confirm this conclusion.

Keywords: Asthma, Helicobacter pylori, Infection, Meta-analysis, Risk

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Wang Y, Bi Y, Zhang L, Wang C. Is Helicobacter Pylori Infection Associated with Asthma Risk? A Meta-Analysis Based on 770 Cases and 785 Controls. Int J Med Sci 2012; 9(7):603-610. doi:10.7150/ijms.4970. Available from http://www.medsci.org/v09p0603.htm