25 September 2018
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Int J Med Sci 2012; 9(6):467-471. doi:10.7150/ijms.4639
Zn2+-SCMC Versus HA for Preventing Intraperitoneal Adhesions: A Rat Model Study
1. Departments of Hepatobiliary Surgery, the Norman Bethune First Hospital of Jilin University, Jilin 130021, China;
Background: Intraperitoneal adhesion is a serious surgical postoperative complication. Using a rat model, we compared the effectiveness of intraperitoneally administered zinc-modified sodium carboxymethyl cellulose (Zn2+-SCMC) and hyaluronic acid (HA) in preventing postoperative intraperitoneal adhesions.
Materials and Methods: Peritoneal adhesions were induced in 120 Wistar rats by scraping the cecal mucosa. The rats were randomized into a no treatment group (n = 40) or into a treatment group in which 3 ml of HA (n = 40) or Zn2+-SCMC (n = 40) was administered intraperitoneally before the abdominal wall was closed. Following sacrifice two weeks later, the intraperitoneal adhesions were scored and tissues were examined histologically using HE staining.
Results: Eight animals died, five in the untreated group (mortality rate, 12.5%), two in the HA group (mortality rate, 5.0%) and one in the Zn2+-SCMC group (mortality rate, 2.5%). Relative to the untreated group, the incidence of intraperitoneal adhesions was 77.5% in the HA and 48.7% in the Zn2+-SCMC group, with the incidence significantly lower in the Zn2+-SCMC group (P < 0.001). Both agents prevented intraperitoneal adhesions by promoting the repair of the abdominal serosa.
Conclusions: Administration of Zn2+-SCMC was more effective in preventing intraperitoneal adhesions than HA.
Keywords: Zn2+-SCMC, HA, intraperitoneal adhesion, abdominal surgery.
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How to cite this article:
Du X, Hong G, Sun P, Liu G. Zn2+-SCMC Versus HA for Preventing Intraperitoneal Adhesions: A Rat Model Study. Int J Med Sci 2012; 9(6):467-471. doi:10.7150/ijms.4639. Available from http://www.medsci.org/v09p0467.htm