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15 December 2017

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Int J Med Sci 2012; 9(2):121-125. doi:10.7150/ijms.3467

Research Paper

Relationship between Antithyroid Antibody and Pregnancy Outcome following in Vitro Fertilization and Embryo Transfer

Yi-ping Zhong#, Ying Ying#, Hai-tao Wu, Can-quan Zhou, Yan-wen Xu, Qiong Wang, Jie Li, Xiao-ting Shen, Jin Li

Reproductive Medicine Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
# Contributed equally

Abstract

Objective: To investigate the impact of antithyroid antibody on pregnancy outcome following the in vitro fertilization and embryo transfer (IVF-ET).

Methods: A total of 90 patients (156 cycles) positive for antithyroid antibody (ATA+ group) and 676 infertile women (1062 cycles) negative for antithyroid antibody (ATA- group) undergoing IVF/ICSI from August 2009 to August 2010 were retrospectively analyzed.

Results: There was no significant difference in the days of ovarian stimulation, total gonadotropin dose, serum E2 level of HCG day and number of oocytes retrieved between the two groups. The fertilization rate, implantation rate and pregnancy rate following IVF-ET were significantly lower in women with antithyroid antibody than in control group (64.3% vs 74.6%, 17.8% vs 27.1% and 33.3% vs 46.7%, respectively), but the abortion rate was significantly higher in patients with antithyroid antibody (26.9% vs 11.8%).

Conclusion: Patients with antithyroid antibody showed significantly lower fertilization rate, implantation rate and pregnancy rate and higher risk for abortion following IVF-ET when compared with those without antithyroid antibody. Thus, the presence of antithyroid antibody is detrimental for the pregnancy outcome following IVF-ET.

Keywords: thyroid auto-antibodies, in vitro fertilization and embryo transfer, pregnancy outcome

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Zhong Yp, Ying Y, Wu Ht, Zhou Cq, Xu Yw, Wang Q, Li J, Shen Xt, Li J. Relationship between Antithyroid Antibody and Pregnancy Outcome following in Vitro Fertilization and Embryo Transfer. Int J Med Sci 2012; 9(2):121-125. doi:10.7150/ijms.3467. Available from http://www.medsci.org/v09p0121.htm