Int J Med Sci 2012; 9(1):108-114. doi:10.7150/ijms.9.108
P-wave Dispersion for Predicting Paroxysmal Atrial Fibrillation in Acute Ischemic Stroke
1. Selcuk University, Meram School of Medicine, Cardiology Department, Meram, Konya, 42080, TURKEY.
2. Selcuk University, Meram School of Medicine, Neurology Department, Meram, Konya, 42080, TURKEY.
Background: Detection of paroxysmal atrial fibrillation (PAF) in acute ischemic stroke patients poses diagnostic challenge. The aim of this study was to predict the presence of PAF by means of 12-lead ECG in patients with acute ischemic stroke. Our hypothesis was that P-wave dispersion (Pd) might be a useful marker in predicting PAF in patients with acute ischemic stroke.
Methods: 12-lead resting ECGs, 24-hour Holter recordings and echocardiograms of 400 patients were analyzed retrospectively. PAF was detected in 40 patients on 24-hour Holter monitoring. Forty out of 360 age and gender matched patients without PAF were randomly chosen and assigned as the control group. Demographics, P-wave characteristics and echocardiographic findings of the patients with and without PAF were compared.
Results: Maximum P-wave duration (p=0.002), Pd (p<0.001) and left atrium diameter (p=0.04) were significantly higher in patients with PAF when compared to patients without PAF. However, in binary logistic regression analysis Pd was the only independent predictor of PAF. The cut-off value of Pd for the detection of PAF was 57.5 milliseconds (msc). Area under the curve was 0.80 (p<0.001). On a single 12-lead ECG, a value higher than 57.5 msc predicted the presence of PAF with a sensitivity of 80% and a specificity of 73%.
Conclusion: Pd on a single 12-lead ECG obtained within 24 hours of an acute ischemic stroke might help to predict PAF and reduce the risk of recurrent strokes.
Keywords: P-wave dispersion, acute ischemic stroke, 12-lead ECG, paroxysmal atrial fibrillation, 24- hour Holter monitoring.
Dogan U, Dogan EA, Tekinalp M, Tokgoz OS, Aribas A, Akilli H, Ozdemir K, Gok H, Yuruten B. P-wave Dispersion for Predicting Paroxysmal Atrial Fibrillation in Acute Ischemic Stroke. Int J Med Sci 2012; 9(1):108-114. doi:10.7150/ijms.9.108. Available from http://www.medsci.org/v09p0108.htm