P-wave Dispersion for Predicting Paroxysmal Atrial Fibrillation in Acute Ischemic Stroke

Dogan, Umuttan; Dogan, Ebru Apaydin; Tekinalp, Mehmet; Tokgoz, Osman Serhat; Aribas, Alpay; Akilli, Hakan; Ozdemir, Kurtulus; Gok, Hasan; Yuruten, Betigul

doi:10.7150/ijms.9.108



Theranostics

International Journal of Biological Sciences

Nanotheranostics

Journal of Cancer

Journal of Genomics

Global reach, higher impact

Full Text | PDF

Int J Med Sci 2012; 9(1):108-114. doi:10.7150/ijms.9.108 This issue Cite

Research Paper

P-wave Dispersion for Predicting Paroxysmal Atrial Fibrillation in Acute Ischemic Stroke

Umuttan Dogan^1✉, Ebru Apaydin Dogan², Mehmet Tekinalp¹, Osman Serhat Tokgoz², Alpay Aribas¹, Hakan Akilli¹, Kurtulus Ozdemir¹, Hasan Gok¹, Betigul Yuruten²

1. Selcuk University, Meram School of Medicine, Cardiology Department, Meram, Konya, 42080, TURKEY.
2. Selcuk University, Meram School of Medicine, Neurology Department, Meram, Konya, 42080, TURKEY.

Citation:

Dogan U, Dogan EA, Tekinalp M, Tokgoz OS, Aribas A, Akilli H, Ozdemir K, Gok H, Yuruten B. P-wave Dispersion for Predicting Paroxysmal Atrial Fibrillation in Acute Ischemic Stroke. Int J Med Sci 2012; 9(1):108-114. doi:10.7150/ijms.9.108. https://www.medsci.org/v09p0108.htm

Other styles

Abstract

Background: Detection of paroxysmal atrial fibrillation (PAF) in acute ischemic stroke patients poses diagnostic challenge. The aim of this study was to predict the presence of PAF by means of 12-lead ECG in patients with acute ischemic stroke. Our hypothesis was that P-wave dispersion (P_d) might be a useful marker in predicting PAF in patients with acute ischemic stroke.

Methods: 12-lead resting ECGs, 24-hour Holter recordings and echocardiograms of 400 patients were analyzed retrospectively. PAF was detected in 40 patients on 24-hour Holter monitoring. Forty out of 360 age and gender matched patients without PAF were randomly chosen and assigned as the control group. Demographics, P-wave characteristics and echocardiographic findings of the patients with and without PAF were compared.

Results: Maximum P-wave duration (p=0.002), P_d (p<0.001) and left atrium diameter (p=0.04) were significantly higher in patients with PAF when compared to patients without PAF. However, in binary logistic regression analysis P_d was the only independent predictor of PAF. The cut-off value of P_d for the detection of PAF was 57.5 milliseconds (msc). Area under the curve was 0.80 (p<0.001). On a single 12-lead ECG, a value higher than 57.5 msc predicted the presence of PAF with a sensitivity of 80% and a specificity of 73%.

Conclusion: P_d on a single 12-lead ECG obtained within 24 hours of an acute ischemic stroke might help to predict PAF and reduce the risk of recurrent strokes.

Keywords: P-wave dispersion, acute ischemic stroke, 12-lead ECG, paroxysmal atrial fibrillation, 24- hour Holter monitoring.

Citation styles

APA

Dogan, U., Dogan, E.A., Tekinalp, M., Tokgoz, O.S., Aribas, A., Akilli, H., Ozdemir, K., Gok, H., Yuruten, B. (2012). P-wave Dispersion for Predicting Paroxysmal Atrial Fibrillation in Acute Ischemic Stroke. International Journal of Medical Sciences, 9(1), 108-114. https://doi.org/10.7150/ijms.9.108.

ACS

Dogan, U.; Dogan, E.A.; Tekinalp, M.; Tokgoz, O.S.; Aribas, A.; Akilli, H.; Ozdemir, K.; Gok, H.; Yuruten, B. P-wave Dispersion for Predicting Paroxysmal Atrial Fibrillation in Acute Ischemic Stroke. Int. J. Med. Sci. 2012, 9 (1), 108-114. DOI: 10.7150/ijms.9.108.

NLM

CSE

Dogan U, Dogan EA, Tekinalp M, Tokgoz OS, Aribas A, Akilli H, Ozdemir K, Gok H, Yuruten B. 2012. P-wave Dispersion for Predicting Paroxysmal Atrial Fibrillation in Acute Ischemic Stroke. Int J Med Sci. 9(1):108-114.

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.