1. Drug Design and Discovery Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C9, Canada 2. Vaccine and Infectious Disease Organization, University of Saskatchewan, 120 Veterinary Road, Saskatoon, SK S7N 5E3, Canada 3. Saskatchewan Structural Sciences Centre, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C9, Canada
✉ Corresponding author: Jian Yang, Drug Design and Discovery Research Group, College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, SK S7N 5C9, Canada. Tel: 306-966-6361; Fax: 306-966-6377; E-mail: jian.yangca
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Citation:
Sun W, Qiao L, Liu Q, Chen L, Ling B, Sammynaiken R, Yang J. Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1. Int J Med Sci 2011; 8(2):161-167. doi:10.7150/ijms.8.161. https://www.medsci.org/v08p0161.htm
Human tumor suppressor gene RIZ encodes two protein products, tumor suppressor RIZ1 and proto-oncoprotein RIZ2, which regulate cellular functions in a Yin-Yang fashion. The only structural difference between them is that RIZ2 lacks the N-terminal PR domain. In this study, we showed that RIZ1 mRNA expression level was elevated in stage IV of eight different types of cancer (stage III for prostate cancer), indicating that RIZ1 might play an important role in tumor metastasis, and the PR domain alone possessed anticancer activity.
Keywords: RIZ1, RIZ, Human tumor suppressor, tumor metastasis
Citation styles
APA
Sun, W., Qiao, L., Liu, Q., Chen, L., Ling, B., Sammynaiken, R., Yang, J. (2011). Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1. International Journal of Medical Sciences, 8(2), 161-167. https://doi.org/10.7150/ijms.8.161.
ACS
Sun, W.; Qiao, L.; Liu, Q.; Chen, L.; Ling, B.; Sammynaiken, R.; Yang, J. Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1. Int. J. Med. Sci. 2011, 8 (2), 161-167. DOI: 10.7150/ijms.8.161.
NLM
Sun W, Qiao L, Liu Q, Chen L, Ling B, Sammynaiken R, Yang J. Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1. Int J Med Sci 2011; 8(2):161-167. doi:10.7150/ijms.8.161. https://www.medsci.org/v08p0161.htm
CSE
Sun W, Qiao L, Liu Q, Chen L, Ling B, Sammynaiken R, Yang J. 2011. Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1. Int J Med Sci. 8(2):161-167.