International Journal of Medical Sciences

Impact factor
2.399

17 December 2017

ISSN 1449-1907 News feeds of published articles

My Manuscript | My Account

Journal of Biomedicinenew

Theranostics

Journal of Cancer

Oncomedicine

International Journal of Biological Sciences

Journal of Genomics

Journal of Bone and Joint Infection (JBJI)

Nanotheranostics

PubMed Central Indexed in Journal Impact Factor

Int J Med Sci 2010; 7(5):300-308. doi:10.7150/ijms.7.300

Research Paper

Genetic polymorphism of p53, but not GSTP1, is association with susceptibility to esophageal cancer risk - A Meta-Analysis

Yaping Zhao1,*, Furu Wang2,3,*, Shunlin Shan4,*, Yiqi Zhao5, Xueming Qiu6, Xiangyang Li4, Feng Jiao5, Jianguo Wang4 , Yunxiang Du4

1. Department of Laboratory, The 82th Hospital of the People's Liberation Army, Huaian 223001,China;
2. Department of Epidemiology and Biostatistics, Cancer Center, Nanjing Medical University, Nanjing 210029, China;
3. JiangSu Provincial Center for Disease Prevention and Control, Nanjing, 210009, China;
4. Department of Oncology, The 82th Hospital of the People's Liberation Army, Huaian 223001, China;
5. Department of Surgery, The 82th Hospital of the People's Liberation Army, Huaian 223001, China;
6. Department of Gastroenterology, The 82th Hospital of the People's Liberation Army, Huaian 223001, China.
* These authors contributed equally to this work.

Abstract

A number of studies have evaluated two functional polymorphisms on p53 Arg72Pro and GSTP1 Ile105Val, in relation to esophageal cancer susceptibility. However, the results remain conflicting rather than conclusive. This meta-analysis on 2919 cases and 4074 controls for p53 Arg72Pro and 1885 cases and 2194 controls for GSTP1 Ile105Val from 13 published case-control studies showed that no significant general main effects for GSTP1 Ile105Val on esophageal cancer risk. However, we found that the p53 Arg72Pro was associated with an increased risk of esophageal cancer ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.20, 95%CI=1.06-1.36) without any between-study heterogeneity.

In the stratified analysis by ethnicity, we found that the increased esophageal cancer risk associated with p53 Arg72Pro polymorphism was more evident in Asian group ((Pro/Arg +Pro/Pro) versus Arg/Arg: OR=1.35, 95%CI=1.14-1.60, P=0.09 for heterogeneity test), although we still failed to find any significant association between GSTP1 Ile105Val polymorphism and esophageal cancer risk in different ethnicity. These results suggest that p53 Arg72Pro polymorphism, but not GSTP1 Ile105Val, may contribute to esophageal cancer development, especially in Asian. Additional well-designed large studies were required for the validation of this association.

Keywords: p53, GSTP1, polymorphism, esophageal cancer, meta-analysis

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Zhao Y, Wang F, Shan S, Zhao Y, Qiu X, Li X, Jiao F, Wang J, Du Y. Genetic polymorphism of p53, but not GSTP1, is association with susceptibility to esophageal cancer risk - A Meta-Analysis. Int J Med Sci 2010; 7(5):300-308. doi:10.7150/ijms.7.300. Available from http://www.medsci.org/v07p0300.htm