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Int J Med Sci 2009; 6(6):374-375. doi:10.7150/ijms.6.374

Case Report

Campylobacter cholecystitis

Deepak Udayakumar 1 Corresponding address, Mohammed Sanaullah 2

1. Resident Physician, Department of Internal Medicine, University of North Dakota, Fargo, ND 58102, USA
2. Attending Physician, Department of Internal Medicine, Meritcare Hospital, 801 Broadway N, Fargo ND 58102, USA

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Udayakumar D, Sanaullah M. Campylobacter cholecystitis. Int J Med Sci 2009; 6(6):374-375. doi:10.7150/ijms.6.374. Available from http://www.medsci.org/v06p0374.htm

Abstract

There are 13 cases of campylobacter cholecystitis reported so far in the medical literature. Among them, only 4 patients had diarrhea. We report another case of acalculous cholecystitis in a setting of campylobacter enteritis. The case report is followed by a literature review regarding this rare condition.

Keywords: Campylobacter cholecystitis, Extra-intestinal manifestations of campylobacter, cholecystitis, campylobacter

Case

A 35-year-old healthy lady presented with high grade fever, severe abdominal pain, nausea, vomiting and profuse watery diarrhea, sometimes green in color. There was no history of animal contact, recent travel or camping. On exam, the patient was hypotensive and was looking acutely ill. Initial labs showed leukocytosis of 11900 with 39% bands. She also had hypokalemia of 3.3 mmol/L, acute kidney injury with elevated creatinine of 1.6 mg/dl from a baseline of 0.6 secondary to dehydration. She was resuscitated with IV fluids, started on empirical Ciprofloxacin and Metronidazole. The patient continued to have abdominal pain. Murphy's sign was positive which prompted us to do a right upper quadrant ultrasound which showed thickened gall bladder wall of upto 1cm consistent with cholecystitis. Stool culture grew campylobacter sensitive to erythromycin. Ciprofloxacin and Metronidazole were changed to Erythromycin and she also underwent a laparoscopic cholecystectomy. The pathology report confirmed acalculous cholecystitis. No sludge was noted. Patient started feeling better after the surgery and was discharged home. During the post-hospitalization follow-up after 2 weeks the patient was asymptomatic except for occasional loose stools.

Discussion

Campylobacter is a small, slender, gram-negative curved rod, which is one of the most common causes of enteritis in humans. Campylobacter fetus may have some attraction towards the gallbladder as in a survey, 20% of slaughtered 700 cattle and sheep harbored this bug in their gallbladder.1

Campylobacter can cause cholecystitis without diarrhea unlike the case that we report here. Please see the table for clinical presentations of the reported cases of campylobacter cholecystitis. The diagnosis of campylobacter cholecystitis is usually missed because culture of campylobacter is not routinely requested after cholecystectomy. However, even if the bile is cultured, campylobacter appears to be a less common cause of cholecystitis. Darling et al cultured about 280 bile samples post cholecystectomy for campylobacter. But none of them grew campylobacter.2 Hence routine ordering of bile culture under microaerophilic condition is not recommended unless the Gram stain shows gram negative curved rods. 3 Resistance of Campylobacter fetus to cephalosporins and penicillins was reported as early as 1986.4 Majority of the reported cases including our patient had good outcome with cholecystectomy and antibiotics especially erythromycin (see Table 1). Only one of the reported cases died, however she had advanced hepatocellular carcinoma.3 There is one case report of relapse of campylobacter bacteremia in a AIDS patient in about 8 months after the first episode of campylobacter cholecystitis.1 In conclusion, campylobacter cholecystitis is rare but should be kept in the back of the mind while treating a patient with campylobacter enteritis.

 Table 1 

List of reported Campylobacter cholecystitis cases.

Author/YearAge/ SexCase presentationTreatment/ Outcome
Darling et al (1979)11 MAbdominal pain, fever, vomitingCholecystectomy and erythromycin
Darling et al (1979)60 FChronic intermittent abdominal pain with occasional obstructive jaundice.Elective cholecystectomy without any antimicrobial therapy. Uneventful recovery.
Darling et al (1979)32 FAbdominal pain, diarrheaCholecystectomy. Uneventful recovery
Mertens et al (1979)52 FAbdominal pain, fever, diarrheaCholecystectomy + chloramphenicol for 5 days. Uneventful recovery
Costel et al (1984)24 MAIDS, pain abdomen, fever. Had a perforated Gallbladder.Cholecystectomy + 2 weeks of erythromycin, tobramycin and nafcillin. Relapse after 8 months with bacteremia
Juliet C et al (1986)46 FBile culture after elective cholecystectomy for cholelithiasis grew Campylobacter.Uneventful after cholecystectomy
Verbruggen et al. (1986)55 MAbdominal painCholecystectomy + Erythromycin. Uneventful recovery
Taziaux P et al (1991)62 MAbdominal painCholecystectomy and erythromycin
Hoop et al (1993)84 FVomiting, diarrheaExplorative laporatomy and Erythromycin. Uneventful recovery
Landau et al (1995)83 MFever, diarrhea, abdominal pain, vomitingCholecystectomy, Ofloxacin
Takatsu et al (1997)64 FAdvanced hepatocellular carcinoma, abdominal pain, feverFosfomycin and Minocycline. Resolution of fever in 3 days of antibiotics. However the patient died secondary to advanced hepatocellular carcinoma
Drion (1998)62 MAbdominal pain, nauseaCholecystectomy + Erythromycin
Hayashi S et al (2005)81 MAbdominal pain, feverAntimicrobial therapy with no cholecystectomy

Conflict of Interest

The authors have declared that no conflict of interest exists.

References

1. Costel EE, Wheeler AP, Gregg CR. Campylobacter fetus ssp fetus cholecystitis and relapsing bacteremia in a patient with acquired immunodeficiency syndrome. South Med J. 1984;77:927-928

2. Darling WM, Peel RN, Skirrow MB, Mulira JL. Campylobacter Cholecystitis. Lancet. 1979;16:1302

3. Takatsu M, Ichiyama S, Toshi N. et al. Campylobacter fetus subsp. fetus cholecystitis in a patient with advanced hepatocellular carcinoma. Scand J Infect Dis. 1997;29:197-198

4. Verbruggen P, Creve U, Hubens A, Verhaegu J. Campylobacter fetus as a cause of acute cholecystitis. Br J Surg. 1986;73:46

Author contact

Corresponding address Correspondence to: Deepak Udayakumar M.D., Department of Internal Medicine, University of North Dakota, 1919 Elm Street North, Fargo, ND 58102. Tel/Mobile: 701 540 3669. Email: dudayakumarnodak.edu


Received 2009-8-18
Accepted 2009-11-23
Published 2009-12-1