International Journal of Medical Sciences

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24 October 2017

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Int J Med Sci 2008; 5(3):152-158. doi:10.7150/ijms.5.152

Research Paper

Of rodents and humans: a light microscopic and ultrastructural study on cardiomyocytes in pulmonary veins

Josef Mueller-Hoecker1, Frigga Beitinger1, Borja Fernandez2, Olaf Bahlmann1, Gerald Assmann1, Christian Troidl3, Ilias Dimomeletis4, Stefan Kääb4, Elisabeth Deindl5

1. Institute of Pathology, Ludwig-Maximillians-University Munich, Germany
2. Faculty of Science, University of Malaga, Spain
3. Kerckhoff Klinik Bad Nauheim, Germany
4. Klinikum Grosshadern, Ludwig-Maximillians-University Munich, Germany
5. Walter-Brendel-Centre of Exp. Medicine, Ludwig-Maximillians-University Munich, Germany

Abstract

Cardiomyocytes in pulmonary veins (PVs) have been reported in rodents and humans. In humans they were related to atrial arrhythmias, including atrial fibrillation (AF). To investigate histological similarities and differences in PV cardiomyocyte localization and distribution, we performed comparative light and electron microscopic studies on humans, rats and mice, and generated a transgenic mouse strain. Results on mice (C57BL/6 and BALBc) and rats (Wistar) revealed that cardiomyocytes regularly extend from the hilus along venous vessels into the lung tissue surrounding individual intrapulmonary veins of varying diameters (70-250µm). The cardiomyocytes showed the ultrastructure of a normal working myocardium with intact intercalated discs and tightly packed contractile filaments. In both lung and hilus cardiomyocytes were localized either close to the basal lamina of the endothelium or separated from it by smooth muscle cells and/or collagen fibres. In humans (autopsies, n=20) extrapericardiac cardiomyocytes were only found in 23 out of 78 veins and showed an incomplete sleeve at the lung hilus. In addition, cardiomyocytes occurred significantly more often in right than in left veins, however, never in intrapulmonary veins.

We discuss the hypothesis that the variance in distribution of PV cardiomyocytes in humans and rodents might reflect the difference in pathogenesis and development of AF.

Keywords: cardiomyocytes, pulmonary veins, electron microscopy, atrial fibrillation

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How to cite this article:
Mueller-Hoecker J, Beitinger F, Fernandez B, Bahlmann O, Assmann G, Troidl C, Dimomeletis I, Kääb S, Deindl E. Of rodents and humans: a light microscopic and ultrastructural study on cardiomyocytes in pulmonary veins. Int J Med Sci 2008; 5(3):152-158. doi:10.7150/ijms.5.152. Available from http://www.medsci.org/v05p0152.htm