International Journal of Medical Sciences

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23 October 2017

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Int J Med Sci 2006; 3(2):69-74. doi:10.7150/ijms.3.69

Review

Treatment of Chronic HCV Infection in Special Populations

John Hoefs1, Vikramjit S. Aulakh2

1. Division of Gastroenterology and Hepatology, H.H. Chao Comprehensive Digestive Disease Center UCI Medical Center, Orange, CA, USA.
2. Mercy Hospital and Medical Center, 2525 S Michigan Ave, Chicago, Illinois, USA.

Abstract

The mainstay of treatment of chronic hepatitis C is pegylated interferon combined with ribavirin and more than 50% of naïve patients will have viral cure with either 6 months (genotypes 2 and 3) or 12 months (genotypes 1,4, and 6) with the initial treatment. However, populations have been defined that respond less well to routine treatment including African Americans, immune suppressed populations, obese patients and cirrhotic patients. These types of patients are enriched in groups of patients who are non-responders to treatment. This article discusses viral kinetics that may impact treatment response, strategies to maximize treatment effectiveness in these populations and the treatment of non-responders in general. Early viral kinetics can be used to define response or non-response and these results can be used to modify subsequent treatment length and dose.

Keywords: HCV, treatment HCV, non-responder, cirrhosis, African American, fatty liver

This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) License. See http://ivyspring.com/terms for full terms and conditions.
How to cite this article:
Hoefs J, Aulakh VS. Treatment of Chronic HCV Infection in Special Populations. Int J Med Sci 2006; 3(2):69-74. doi:10.7150/ijms.3.69. Available from http://www.medsci.org/v03p0069.htm