Int J Med Sci 2004; 1(1):43-49. doi:10.7150/ijms.1.43

Cribriform-Morular Variant of Papillary Carcinoma: Association with Familial Adenomatous Polyposis - Report of Three Cases and Review of Literature

Shylashree Chikkamuniyappa , Jaishree Jagirdar

Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229-3900, USA

Abstract

We describe a rare variant of papillary thyroid carcinoma (PTC), the Cribriform-Morular Variant (C-MV). A handful of cases have been described in the literature of this entity. They exhibit the morphologic features of a distinctive papillary neoplasm along with solid, cribriform, and squamoid-morular areas. The cribriform and morular features make this a separate entity which could be mistaken for a high grade aggressive thyroid neoplasm. These lesions are usually associated with familial adenomatosis polyposis (FAP) but rarely may be sporadic. We report three cases that we have encountered.

Keywords: thyroid neoplasm, papillary thyroid carcinoma, cribriform, squamoid, morular

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How to cite this article:
Chikkamuniyappa S, Jagirdar J. Cribriform-Morular Variant of Papillary Carcinoma: Association with Familial Adenomatous Polyposis - Report of Three Cases and Review of Literature. Int J Med Sci 2004; 1(1):43-49. doi:10.7150/ijms.1.43. Available from http://www.medsci.org/v01p0043.htm